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PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 [ Homo sapiens (human) ]

Gene ID: 9677, updated on 27-Nov-2024

Summary

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Official Symbol
PPIP5K1provided by HGNC
Official Full Name
diphosphoinositol pentakisphosphate kinase 1provided by HGNC
Primary source
HGNC:HGNC:29023
See related
Ensembl:ENSG00000168781 MIM:610979; AllianceGenome:HGNC:29023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP6K; IPS1; VIP1; hsVIP1; HISPPD2A
Summary
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in duodenum (RPKM 8.8), small intestine (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

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See PPIP5K1 in Genome Data Viewer
Location:
15q15.3
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43533475..43590253, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (41340826..41397612, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43825673..43882451, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43734212-43734815 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43769402-43769643 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:43784380-43785088 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:43785089-43785795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43787292-43787792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43810281-43810924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43819912-43820544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43821526-43822026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43822027-43822527 Neighboring gene microtubule associated protein 1A Neighboring gene RNA, U6 small nuclear 554, pseudogene Neighboring gene creatine kinase, mitochondrial 1B Neighboring gene stereocilin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family. Shears SB, et al. Adv Biol Regul, 2017 Jan. PMID 27776974, Free PMC Article
  2. PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility. Machkalyan G, et al. Cell Signal, 2016 May. PMID 26854614
  3. Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain. Gokhale NA, et al. Biochem J, 2011 Mar 15. PMID 21222653, Free PMC Article
  4. The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis. Gu C, et al. J Biol Chem, 2017 Mar 17. PMID 28126903, Free PMC Article
  5. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. Choi JH, et al. J Biol Chem, 2007 Oct 19. PMID 17702752, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPIP5K is a rare example of a single protein that catalyzes a kinase/phosphatase futile cycle. (Review)
    Title: The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family.
  2. This study characterized kinetic properties of the bifunctional inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphatekinase/inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate phosphatase activities of full-length diphosphoinositol pentakisphosphate kinase 1 and 2.
    Title: The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.
  3. results suggest that PPIP5K1 might play an important role in regulating function of exocyst complex in establishing cellular polarity and directional migration of cells
    Title: PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.
  4. Upon activation of the appropriate cell-surface receptors to stimulate PtdIns(3,4,5)P3 synthesis, human PPIP5K1 translocates from the cytoplasm to the plasma membrane.
    Title: Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0377, MGC51871, DKFZp313L0221

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables diphosphoinositol pentakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diphosphoinositol pentakisphosphate kinase activity TAS
Traceable Author Statement
more info
  
enables inositol hexakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol hexakisphosphate kinase activity TAS
Traceable Author Statement
more info
  
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Names
IP6 kinase
VIP1 homolog
histidine acid phosphatase domain containing 2A
histidine acid phosphatase domain-containing protein 2A
inositol pyrophosphate synthase 1
insP6 and PP-IP5 kinase 1
NP_001124330.1
NP_001124331.1
NP_001177143.1
NP_001341311.1
NP_001341312.1
NP_001341313.1
NP_001341314.1
NP_001341315.1
NP_001341316.1
NP_001341317.1
NP_001341318.1
NP_001341319.1
NP_001341320.1
NP_001341321.1
NP_001341322.1
NP_001341323.1
NP_001341324.1
NP_001341325.1
NP_001341326.1
NP_001341327.1
NP_001341328.1
NP_001341329.1
NP_001341330.1
NP_001341331.1
NP_001380898.1
NP_001380899.1
NP_001380900.1
NP_001381324.1
NP_055474.3
XP_005254861.1
XP_006720849.1
XP_011520551.1
XP_011520552.1
XP_011520554.1
XP_011520556.1
XP_011520560.1
XP_016878225.1
XP_016878226.1
XP_016878236.1
XP_016878242.1
XP_016878243.1
XP_047289332.1
XP_047289333.1
XP_047289334.1
XP_047289335.1
XP_047289336.1
XP_047289337.1
XP_047289338.1
XP_047289339.1
XP_047289340.1
XP_047289341.1
XP_047289342.1
XP_047289343.1
XP_047289344.1
XP_047289345.1
XP_047289346.1
XP_054235239.1
XP_054235240.1
XP_054235241.1
XP_054235242.1
XP_054235243.1
XP_054235244.1
XP_054235245.1
XP_054235246.1
XP_054235247.1
XP_054235248.1
XP_054235249.1
XP_054235250.1
XP_054235251.1
XP_054235252.1
XP_054235253.1
XP_054235254.1
XP_054235255.1
XP_054235256.1
XP_054235257.1
XP_054235258.1
XP_054235259.1
XP_054235260.1
XP_054235261.1
XP_054235262.1
XP_054235263.1
XP_054235264.1
XP_054235265.1
XP_054235266.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_022929.1 RefSeqGene

    Range
    5046..61779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130858.4 → NP_001124330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 5

    See identical proteins and their annotated locations for NP_001124330.1

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS45252.1
    UniProtKB/Swiss-Prot
    O15082, Q5HYF8, Q6PFW1, Q7Z3A7, Q86TE7, Q86UV3, Q86UV4, Q86XW8, Q8IZN0
    UniProtKB/TrEMBL
    F8W9A8
    Related
    ENSP00000380129.2, ENST00000396923.7
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 910
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  2. NM_001130859.3 → NP_001124331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001124331.1

    Status: REVIEWED

    Source sequence(s)
    AC011330, BC057395, BX538022, DB065605
    Consensus CDS
    CCDS32215.1
    UniProtKB/TrEMBL
    F8W9A8
    Related
    ENSP00000334779.4, ENST00000334933.8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  3. NM_001190214.2 → NP_001177143.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 6

    See identical proteins and their annotated locations for NP_001177143.1

    Status: REVIEWED

    Source sequence(s)
    AB002375, AC011330, AC019011, AI638651, DB065605
    Consensus CDS
    CCDS53937.1
    UniProtKB/TrEMBL
    F8W9A8
    Related
    ENSP00000353253.4, ENST00000360135.8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  4. NM_001354382.3 → NP_001341311.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    UniProtKB/TrEMBL
    B7WPL9, F8W9A8
    Related
    ENSP00000371309.1, ENST00000381885.5
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  5. NM_001354383.2 → NP_001341312.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    UniProtKB/TrEMBL
    B7WPL9, F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  6. NM_001354384.2 → NP_001341313.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    UniProtKB/TrEMBL
    B7WPL9, F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  7. NM_001354385.2 → NP_001341314.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    UniProtKB/TrEMBL
    B7WPL9, F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  8. NM_001354386.2 → NP_001341315.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS86452.1
    UniProtKB/TrEMBL
    B7WPL9, F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  9. NM_001354387.2 → NP_001341316.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  10. NM_001354388.2 → NP_001341317.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  11. NM_001354389.2 → NP_001341318.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  12. NM_001354390.2 → NP_001341319.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  13. NM_001354391.2 → NP_001341320.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  14. NM_001354392.2 → NP_001341321.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  15. NM_001354393.2 → NP_001341322.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  16. NM_001354394.2 → NP_001341323.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 878
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  17. NM_001354395.2 → NP_001341324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  18. NM_001354396.2 → NP_001341325.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  19. NM_001354397.2 → NP_001341326.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  20. NM_001354398.2 → NP_001341327.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:135 → 651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  21. NM_001354399.2 → NP_001341328.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:135 → 651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  22. NM_001354400.2 → NP_001341329.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:135 → 651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  23. NM_001354401.2 → NP_001341330.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    cl11399
    Location:5 → 242
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cl27087
    Location:547 → 654
    SPOR; Sporulation related domain

  24. NM_001354402.2 → NP_001341331.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Conserved Domains (2) summary
    cl11399
    Location:5 → 234
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cl27087
    Location:518 → 625
    SPOR; Sporulation related domain

  25. NM_001393969.1 → NP_001380898.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    A0A9L9PYJ9, F8W9A8
    Conserved Domains (2) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:55 → 144
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  26. NM_001393970.1 → NP_001380899.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    A0A9L9PYJ9, F8W9A8
    Related
    ENSP00000516724.1, ENST00000707073.1
    Conserved Domains (2) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)
    pfam18086
    Location:55 → 144
    PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

  27. NM_001393971.1 → NP_001380900.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    cd07061
    Location:525 → 894
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  28. NM_001394395.1 → NP_001381324.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS91989.1
    UniProtKB/TrEMBL
    A0A8J8ZH50, F8W9A8
    Related
    ENSP00000400887.2, ENST00000420765.6
    Conserved Domains (1) summary
    cd07061
    Location:525 → 902
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  29. NM_014659.6 → NP_055474.3  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_055474.3

    Status: REVIEWED

    Source sequence(s)
    AC011330, AC019011
    Consensus CDS
    CCDS32215.1
    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43533475..43590253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433387.1 → XP_047289343.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

  2. XM_047433384.1 → XP_047289340.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

  3. XM_047433381.1 → XP_047289337.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B7WPL9
    Related
    ENSP00000371303.4, ENST00000381879.8

  4. XM_047433380.1 → XP_047289336.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A9L9PYJ9

  5. XM_011522254.2 → XP_011520556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520556.1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  6. XM_047433377.1 → XP_047289333.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  7. XM_017022753.2 → XP_016878242.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 898
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  8. XM_011522252.2 → XP_011520554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520554.1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  9. XM_047433390.1 → XP_047289346.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

  10. XM_047433379.1 → XP_047289335.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

  11. XM_006720786.3 → XP_006720849.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  12. XM_005254804.1 → XP_005254861.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

    See identical proteins and their annotated locations for XP_005254861.1

    UniProtKB/TrEMBL
    F8W9A8
    Related
    ENSP00000353446.4, ENST00000360301.8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  13. XM_011522249.1 → XP_011520551.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520551.1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  14. XM_047433389.1 → XP_047289345.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  15. XM_047433382.1 → XP_047289338.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B7WPL9

  16. XM_047433386.1 → XP_047289342.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

  17. XM_047433383.1 → XP_047289339.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

  18. XM_017022754.2 → XP_016878243.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  19. XM_047433385.1 → XP_047289341.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

  20. XM_047433376.1 → XP_047289332.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  21. XM_017022737.2 → XP_016878226.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  22. XM_047433388.1 → XP_047289344.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  23. XM_011522250.2 → XP_011520552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520552.1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  24. XM_017022736.2 → XP_016878225.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  25. XM_047433378.1 → XP_047289334.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  26. XM_017022747.2 → XP_016878236.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:390 → 906
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

  27. XM_011522258.2 → XP_011520560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

    UniProtKB/TrEMBL
    F8W9A8
    Conserved Domains (1) summary
    pfam00328
    Location:135 → 651
    His_Phos_2; Histidine phosphatase superfamily (branch 2)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    41340826..41397612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379284.1 → XP_054235259.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

  2. XM_054379278.1 → XP_054235253.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

  3. XM_054379275.1 → XP_054235250.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B7WPL9

  4. XM_054379274.1 → XP_054235249.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A9L9PYJ9

  5. XM_054379268.1 → XP_054235243.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  6. XM_054379270.1 → XP_054235245.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  7. XM_054379283.1 → XP_054235258.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

  8. XM_054379266.1 → XP_054235241.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  9. XM_054379289.1 → XP_054235264.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

  10. XM_054379273.1 → XP_054235248.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

  11. XM_054379285.1 → XP_054235260.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  12. XM_054379280.1 → XP_054235255.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

  13. XM_054379264.1 → XP_054235239.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  14. XM_054379288.1 → XP_054235263.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  15. XM_054379276.1 → XP_054235251.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

    UniProtKB/TrEMBL
    B7WPL9

  16. XM_054379282.1 → XP_054235257.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

  17. XM_054379277.1 → XP_054235252.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

  18. XM_054379287.1 → XP_054235262.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  19. XM_054379281.1 → XP_054235256.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

  20. XM_054379265.1 → XP_054235240.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  21. XM_054379267.1 → XP_054235242.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  22. XM_054379286.1 → XP_054235261.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

  23. XM_054379271.1 → XP_054235246.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  24. XM_054379269.1 → XP_054235244.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  25. XM_054379272.1 → XP_054235247.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

  26. XM_054379279.1 → XP_054235254.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

  27. XM_054379290.1 → XP_054235265.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

  28. XM_054379291.1 → XP_054235266.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X12

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024463.3: Suppressed sequence

    Description
    NM_001024463.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns to the reference genome with non-consensus splice sites.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFW1.1 GenPept UniProtKB/Swiss-Prot:Q6PFW1

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