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Susd4 sushi domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 96935, updated on 27-Nov-2024

Summary

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Official Symbol
Susd4provided by MGI
Official Full Name
sushi domain containing 4provided by MGI
Primary source
MGI:MGI:2138351
See related
Ensembl:ENSMUSG00000038576 AllianceGenome:MGI:2138351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430021N18Rik
Summary
Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in parallel fiber to Purkinje cell synapse and postsynaptic membrane. Is expressed in brain and cortical plate. Orthologous to human SUSD4 (sushi domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 29.8), cortex adult (RPKM 26.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Susd4 in Genome Data Viewer
Location:
1 H5; 1 85.94 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (182591609..182724161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (182764044..182896596)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calpain 8 Neighboring gene coiled-coil domain containing 185 Neighboring gene STARR-seq mESC enhancer starr_03290 Neighboring gene STARR-seq mESC enhancer starr_03291 Neighboring gene STARR-seq mESC enhancer starr_03292 Neighboring gene STARR-seq mESC enhancer starr_03293 Neighboring gene STARR-seq mESC enhancer starr_03294 Neighboring gene toll-like receptor 5 Neighboring gene predicted gene, 33747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. González-Calvo I, et al. Elife, 2021 Mar 4. PMID 33661101, Free PMC Article
  2. Tissue distribution and functional analysis of Sushi domain-containing protein 4. Tu Z, et al. Am J Pathol, 2010 May. PMID 20348246, Free PMC Article
  3. The Complement Regulator Susd4 Influences Nervous-System Function and Neuronal Morphology in Mice. Zhu H, et al. iScience, 2020 Mar 27. PMID 32179479, Free PMC Article
  4. Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. Hai Q, et al. Arterioscler Thromb Vasc Biol, 2018 Jan. PMID 29097366, Free PMC Article
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
    Title: Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
  2. analysis of cloning, expression, refolding, and tissue distribution of Sushi domain-containing protein 4
    Title: Tissue distribution and functional analysis of Sushi domain-containing protein 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC30368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of complement activation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
sushi domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356461.1 → NP_001343390.1  sushi domain-containing protein 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151579, AC170917
    Consensus CDS
    CCDS15590.1
    UniProtKB/Swiss-Prot
    Q8BH32, Q8VC43
    Related
    ENSMUSP00000119488.2, ENSMUST00000153348.8
    Conserved Domains (2) summary
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

  2. NM_001356462.1 → NP_001343391.1  sushi domain-containing protein 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151579, AC170917
    Consensus CDS
    CCDS15590.1
    UniProtKB/Swiss-Prot
    Q8BH32, Q8VC43
    Conserved Domains (2) summary
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

  3. NM_001356463.1 → NP_001343392.1  sushi domain-containing protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151579, AC170917
    Conserved Domains (2) summary
    smart00032
    Location:245 → 299
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

  4. NM_001356464.1 → NP_001343393.1  sushi domain-containing protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC151579, AC170917
    Conserved Domains (2) summary
    smart00032
    Location:245 → 299
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

  5. NM_144796.5 → NP_659045.2  sushi domain-containing protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_659045.2

    Status: VALIDATED

    Source sequence(s)
    AC151579, AC170917
    Consensus CDS
    CCDS15590.1
    UniProtKB/Swiss-Prot
    Q8BH32, Q8VC43
    Related
    ENSMUSP00000082873.4, ENSMUST00000085724.5
    Conserved Domains (2) summary
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    182591609..182724161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243824.2 → XP_030099684.1  sushi domain-containing protein 4 isoform X3

    Conserved Domains (2) summary
    cd00033
    Location:81 → 138
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:35 → 197
    PHA02927; secreted complement-binding protein; Provisional

  2. XM_030243823.1 → XP_030099683.1  sushi domain-containing protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8BH32, Q8VC43
    Conserved Domains (2) summary
    smart00032
    Location:243 → 297
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional

  3. XM_006497063.2 → XP_006497126.1  sushi domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006497126.1

    UniProtKB/Swiss-Prot
    Q8BH32
    Conserved Domains (2) summary
    smart00032
    Location:245 → 299
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:57 → 238
    PHA02927; secreted complement-binding protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH32.1 GenPept UniProtKB/Swiss-Prot:Q8BH32

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