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GPRIN2 G protein regulated inducer of neurite outgrowth 2 [ Homo sapiens (human) ]

Gene ID: 9721, updated on 27-Nov-2024

Summary

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Official Symbol
GPRIN2provided by HGNC
Official Full Name
G protein regulated inducer of neurite outgrowth 2provided by HGNC
Primary source
HGNC:HGNC:23730
See related
Ensembl:ENSG00000204175 MIM:611240; AllianceGenome:HGNC:23730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRIN2; KIAA0514
Summary
Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in lung (RPKM 5.6), skin (RPKM 4.9) and 12 other tissues See more
Orthologs
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Genomic context

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See GPRIN2 in Genome Data Viewer
Location:
10q11.22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46541736..46557596, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (47428090..47443951, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46992021..47007881)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 842 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124851-47125351 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47124350-47124850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47107598-47108554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47101901-47102401 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:47089605-47090205 Neighboring gene neuropeptide Y receptor Y4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:47033702-47034570 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47034571-47035439 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47047925-47048424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47057528-47058124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47021543-47022511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:47013295-47013796 Neighboring gene uncharacterized LOC124902419 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47008064-47008694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46992923-46993628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46991512-46992217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46975535-46976296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974774-46975534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:46974012-46974773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46969747-46970624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:46968867-46969746 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 1 Neighboring gene SYT15 antisense RNA 1 Neighboring gene uncharacterized LOC105378289 Neighboring gene synaptotagmin 15 Neighboring gene shieldin complex subunit 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Familial Esophageal Squamous Cell Carcinoma with damaging rare/germline mutations in KCNJ12/KCNJ18 and GPRIN2 genes. Khalilipour N, et al. Cancer Genet, 2018 Feb. PMID 29405996
  2. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
  3. A candidate target for G protein action in brain. Chen LT, et al. J Biol Chem, 1999 Sep 17. PMID 10480904
  4. Protein interactions of the transcription factor Hoxa1. Lambert B, et al. BMC Dev Biol, 2012 Oct 22. PMID 23088713, Free PMC Article
  5. Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Benzinger A, et al. Mol Cell Proteomics, 2005 Jun. PMID 15778465

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC15171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G protein-regulated inducer of neurite outgrowth 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385275.1 → NP_001372204.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  2. NM_001385276.1 → NP_001372205.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  3. NM_001385277.1 → NP_001372206.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  4. NM_001385278.1 → NP_001372207.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Related
    ENSP00000363436.1, ENST00000374317.2
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  5. NM_001385279.1 → NP_001372208.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  6. NM_001385280.1 → NP_001372209.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  7. NM_001385281.1 → NP_001372210.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  8. NM_001385282.1 → NP_001372211.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Related
    ENSP00000363433.4, ENST00000374314.6
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  9. NM_001385283.1 → NP_001372212.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  10. NM_001385287.1 → NP_001372216.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  11. NM_001385289.1 → NP_001372218.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  12. NM_001385291.1 → NP_001372220.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  13. NM_001385293.1 → NP_001372222.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  14. NM_001385294.1 → NP_001372223.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  15. NM_001385295.1 → NP_001372224.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  16. NM_001385296.1 → NP_001372225.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  17. NM_001385297.1 → NP_001372226.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  18. NM_001385298.1 → NP_001372227.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  19. NM_001385299.1 → NP_001372228.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  20. NM_001385300.1 → NP_001372229.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  21. NM_001385301.1 → NP_001372230.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  22. NM_001394739.1 → NP_001381668.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  23. NM_001394740.1 → NP_001381669.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  24. NM_001394741.1 → NP_001381670.1  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  25. NM_001394742.1 → NP_001381671.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  26. NM_001394743.1 → NP_001381672.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  27. NM_001394744.1 → NP_001381673.1  G protein-regulated inducer of neurite outgrowth 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  28. NM_014696.5 → NP_055511.2  G protein-regulated inducer of neurite outgrowth 2 isoform 1

    See identical proteins and their annotated locations for NP_055511.2

    Status: VALIDATED

    Source sequence(s)
    AL356056, AL645529, AL732434
    Consensus CDS
    CCDS73101.1
    UniProtKB/Swiss-Prot
    O60269, Q5SVF0
    Conserved Domains (1) summary
    pfam15235
    Location:349 → 450
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    46541736..46557596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016981.3 → XP_016872470.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  2. XM_017016982.3 → XP_016872471.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  3. XM_017016974.3 → XP_016872463.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  4. XM_017016984.3 → XP_016872473.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  5. XM_017016983.3 → XP_016872472.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  6. XM_017016976.3 → XP_016872465.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  7. XM_017016977.3 → XP_016872466.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  8. XM_017016975.3 → XP_016872464.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

  9. XM_017016978.3 → XP_016872467.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

    Conserved Domains (1) summary
    pfam15235
    Location:373 → 474
    GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160001.1 Reference GRCh38.p14 PATCHES

    Range
    45021..60864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    47428090..47443951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367243.1 → XP_054223218.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

  2. XM_054367242.1 → XP_054223217.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

  3. XM_054367241.1 → XP_054223216.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

  4. XM_054367240.1 → XP_054223215.1  G protein-regulated inducer of neurite outgrowth 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60269.2 GenPept UniProtKB/Swiss-Prot:O60269

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