Dcaf8 DDB1 and CUL4 associated factor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dcaf8provided by MGI
Official Full Name: DDB1 and CUL4 associated factor 8provided by MGI
Primary source: MGI:MGI:91860
See related: Ensembl:ENSMUSG00000026554 AllianceGenome:MGI:91860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H326; Wdr42a; D1Ucla4; D1Dau35e
Summary: Acts upstream of or within myotube cell development. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including cerebral cortex; liver; lung; metanephros; and spleen. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to human DCAF8 (DDB1 and CUL4 associated factor 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 29.6), kidney adult (RPKM 26.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171975574..172023959)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172148015..172196393)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.
Title: DDB1- and CUL4-associated factor 8 plays a critical role in spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124784 (e-PCR)
- UniSTS:161606

RH136526 (e-PCR)
- UniSTS:210508

G42026 (e-PCR)
- UniSTS:105051

G42043 (e-PCR)
- UniSTS:105068

G42044 (e-PCR)
- UniSTS:105069

C76055 (e-PCR)
- UniSTS:158889

D1Ucla4 (e-PCR), detects polymorphism
- UniSTS:142280

RH124938 (e-PCR)
- UniSTS:161760

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within myotube cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 8

Names: WD repeat domain 42A; WD repeat-containing protein 42A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357204.2 → NP_001344133.1 DDB1- and CUL4-associated factor 8 isoform 1

Status: VALIDATED

Source sequence(s)

AC074310

Consensus CDS

CCDS15509.1

UniProtKB/Swiss-Prot

Q8CII7, Q8CIK6, Q8N7N5

Related

ENSMUSP00000141732.2, ENSMUST00000192704.6

Conserved Domains (3) summary

TIGR00927
Location:17 → 177

2A1904; K+-dependent Na+/Ca+ exchanger

sd00039
Location:192 → 228

7WD40; WD40 repeat [structural motif]

cl29593
Location:183 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001421210.1 → NP_001408139.1 DDB1- and CUL4-associated factor 8 isoform 1

Status: VALIDATED

Source sequence(s)

AC074310

UniProtKB/Swiss-Prot

Q8CII7, Q8CIK6, Q8N7N5

Related

ENSMUSP00000073778.6, ENSMUST00000074144.11
NM_001421211.1 → NP_001408140.1 DDB1- and CUL4-associated factor 8 isoform 1

Status: VALIDATED

Source sequence(s)

AC074310

UniProtKB/Swiss-Prot

Q8CII7, Q8CIK6, Q8N7N5
NM_001421212.1 → NP_001408141.1 DDB1- and CUL4-associated factor 8 isoform 2

Status: VALIDATED

Source sequence(s)

AC074310
NM_001421213.1 → NP_001408142.1 DDB1- and CUL4-associated factor 8 isoform 2

Status: VALIDATED

Source sequence(s)

AC074310
NM_001421214.1 → NP_001408143.1 DDB1- and CUL4-associated factor 8 isoform 3

Status: VALIDATED

Source sequence(s)

AC074310
NM_001421215.1 → NP_001408144.1 DDB1- and CUL4-associated factor 8 isoform 4

Status: VALIDATED

Source sequence(s)

AC074310
NM_153555.3 → NP_705783.1 DDB1- and CUL4-associated factor 8 isoform 1

See identical proteins and their annotated locations for NP_705783.1

Status: VALIDATED

Source sequence(s)

AC074310

Consensus CDS

CCDS15509.1

UniProtKB/Swiss-Prot

Q8CII7, Q8CIK6, Q8N7N5

Related

ENSMUSP00000141731.2, ENSMUST00000191689.6

Conserved Domains (3) summary

TIGR00927
Location:17 → 177

2A1904; K+-dependent Na+/Ca+ exchanger

sd00039
Location:192 → 228

7WD40; WD40 repeat [structural motif]

cl29593
Location:183 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...