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CEP170 centrosomal protein 170 [ Homo sapiens (human) ]

Gene ID: 9859, updated on 27-Nov-2024

Summary

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Official Symbol
CEP170provided by HGNC
Official Full Name
centrosomal protein 170provided by HGNC
Primary source
HGNC:HGNC:28920
See related
Ensembl:ENSG00000143702 MIM:613023; AllianceGenome:HGNC:28920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAB; FAM68A; KIAA0470
Summary
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 12.9), testis (RPKM 11.4) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See CEP170 in Genome Data Viewer
Location:
1q43
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (243124428..243255785, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (242535446..242666489, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (243287730..243418583, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1347 Neighboring gene uncharacterized LOC124904568 Neighboring gene RNA, U6 small nuclear 747, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:243277095-243277846 Neighboring gene NANOG hESC enhancer GRCh37_chr1:243285114-243285617 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:243337129-243337774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243338714-243339414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243339415-243340113 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:243431137-243432336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243448123-243448859 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene FCF1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 8354 Neighboring gene microRNA 4677

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning. Pizon V, et al. Biol Cell, 2020 Jan. PMID 31789463
  2. A SEPT1-based scaffold is required for Golgi integrity and function. Song K, et al. J Cell Sci, 2019 Feb 1. PMID 30709970, Free PMC Article
  3. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. Welburn JP, et al. Mol Biol Cell, 2012 Dec. PMID 23087211, Free PMC Article
  4. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Bärenz F, et al. Mol Biol Cell, 2018 Dec 15. PMID 30354798, Free PMC Article
  5. The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. Kolobova E, et al. J Biol Chem, 2017 Dec 15. PMID 29054927, Free PMC Article

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
    Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
  2. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
    Title: Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
  3. SEPT1 function depends on the Golgi matrix protein GOLGA2 and on centrosomal proteins, including CEP170 and components of gamma-tubulin ring complex, to facilitate the perinuclear concentration of Golgi membranes.
    Title: A SEPT1-based scaffold is required for Golgi integrity and function.
  4. Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
    Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
  5. Data suggest that CDK5RAP2 and CEP170 both interact with microtubule nucleation-promoting region of AKAP350A; CEP68 interacts with distal C-terminal region of AKAP350A; AKAP350A spans the bridge between centrioles. (CDK5RAP2 = CDK5 regulatory subunit associated protein 2; CEP170 = centrosomal protein 170kDa; AKAP350A = A kinase (PRKA) anchor protein (yotiao) 9; CEP68 = centrosomal protein 68kDa)
    Title: The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins.
  6. Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle.
    Title: The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
  9. Cep170 interacts with Polo-like kinase 1 in mature centrioles.
    Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with CEP170 PubMed
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with centrosomal protein 170kDa (CEP170) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of centriolar subdistal appendage IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 170 kDa
Names
KARP-1-binding protein
XRCC5 binding protein
centrosomal protein 170kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029663.2 RefSeqGene

    Range
    5126..135979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042404.2 → NP_001035863.1  centrosomal protein of 170 kDa isoform beta

    See identical proteins and their annotated locations for NP_001035863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta, also known as 2) lacks an alternate in-frame exon, compared to variant alpha, resulting in a shorter protein (isoform beta), compared to isoform alpha.
    Source sequence(s)
    AB022658, AC092782, AL606534, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44337.1
    UniProtKB/TrEMBL
    B2RTS4
    Related
    ENSP00000355502.1, ENST00000366544.6
    Conserved Domains (3) summary
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:713 → 1408
    CEP170_C; CEP170 C-terminus

  2. NM_001042405.2 → NP_001035864.1  centrosomal protein of 170 kDa isoform gamma

    See identical proteins and their annotated locations for NP_001035864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma, also known as 3) has multiple differences in the coding region but maintains the reading frame, compared to variant alpha, resulting in a shorter protein (isoform gamma), compared to isoform alpha.
    Source sequence(s)
    AB022659, AC092782, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44338.1
    UniProtKB/TrEMBL
    A6H8X9
    Related
    ENSP00000355501.1, ENST00000366543.5
    Conserved Domains (3) summary
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:713 → 1382
    CEP170_C; CEP170 C-terminus

  3. NM_014812.3 → NP_055627.2  centrosomal protein of 170 kDa isoform alpha

    See identical proteins and their annotated locations for NP_055627.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha, also known as 1) represents the longest transcript and encodes the longest isoform (alpha).
    Source sequence(s)
    AB022657, AC092782, AL606534, BP349206, BP349680, CB410835
    Consensus CDS
    CCDS44339.1
    UniProtKB/Swiss-Prot
    O75058, Q5SW77, Q5SW78, Q5SW79, Q7LGA9, Q86W31, Q9UQ08, Q9UQ09
    UniProtKB/TrEMBL
    B2RTS4
    Related
    ENSP00000355500.1, ENST00000366542.6
    Conserved Domains (4) summary
    pfam09528
    Location:353 → 854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:811 → 1506
    CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    243124428..243255785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435483.1 → XP_047291439.1  centrosomal protein of 170 kDa isoform X1

  2. XM_006711843.5 → XP_006711906.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_006711906.1

    UniProtKB/TrEMBL
    H0Y2V6
    Related
    ENSP00000338161.4, ENST00000336415.8
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1578
    CEP170_C; CEP170 C-terminus

  3. XM_017002951.3 → XP_016858440.1  centrosomal protein of 170 kDa isoform X18

    UniProtKB/TrEMBL
    B2RTS4

  4. XM_017002946.3 → XP_016858435.1  centrosomal protein of 170 kDa isoform X16

    UniProtKB/TrEMBL
    B2RTS4

  5. XM_011544343.4 → XP_011542645.1  centrosomal protein of 170 kDa isoform X12

    See identical proteins and their annotated locations for XP_011542645.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:307 → 757
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:714 → 1419
    CEP170_C; CEP170 C-terminus

  6. XM_017002949.3 → XP_016858438.1  centrosomal protein of 170 kDa isoform X17

    UniProtKB/TrEMBL
    A6H8X9

  7. XM_017002947.3 → XP_016858436.1  centrosomal protein of 170 kDa isoform X15

    UniProtKB/TrEMBL
    A6H8X9

  8. XM_017002945.3 → XP_016858434.1  centrosomal protein of 170 kDa isoform X14

    UniProtKB/TrEMBL
    B2RTS4

  9. XM_011544344.4 → XP_011542646.1  centrosomal protein of 170 kDa isoform X13

    See identical proteins and their annotated locations for XP_011542646.1

    UniProtKB/TrEMBL
    B2RTS4
    Conserved Domains (3) summary
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:713 → 1418
    CEP170_C; CEP170 C-terminus

  10. XM_017002942.3 → XP_016858431.1  centrosomal protein of 170 kDa isoform X11

    UniProtKB/TrEMBL
    A6H8X9

  11. XM_017002938.3 → XP_016858427.1  centrosomal protein of 170 kDa isoform X10

    UniProtKB/TrEMBL
    A6H8X9

  12. XM_017002937.3 → XP_016858426.1  centrosomal protein of 170 kDa isoform X9

    UniProtKB/TrEMBL
    A6H8X9

  13. XM_017002935.3 → XP_016858424.1  centrosomal protein of 170 kDa isoform X8

    UniProtKB/TrEMBL
    B2RTS4

  14. XM_011544341.4 → XP_011542643.1  centrosomal protein of 170 kDa isoform X6

    See identical proteins and their annotated locations for XP_011542643.1

    UniProtKB/TrEMBL
    B2RTS4
    Conserved Domains (4) summary
    pfam09528
    Location:353 → 854
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:811 → 1516
    CEP170_C; CEP170 C-terminus

  15. XM_011544342.4 → XP_011542644.1  centrosomal protein of 170 kDa isoform X7

    See identical proteins and their annotated locations for XP_011542644.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1515
    CEP170_C; CEP170 C-terminus

  16. XM_011544340.4 → XP_011542642.1  centrosomal protein of 170 kDa isoform X5

    See identical proteins and their annotated locations for XP_011542642.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1532
    CEP170_C; CEP170 C-terminus

  17. XM_011544339.4 → XP_011542641.1  centrosomal protein of 170 kDa isoform X4

    See identical proteins and their annotated locations for XP_011542641.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1542
    CEP170_C; CEP170 C-terminus

  18. XM_011544338.4 → XP_011542640.1  centrosomal protein of 170 kDa isoform X3

    See identical proteins and their annotated locations for XP_011542640.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1551
    CEP170_C; CEP170 C-terminus

  19. XM_011544337.4 → XP_011542639.1  centrosomal protein of 170 kDa isoform X2

    See identical proteins and their annotated locations for XP_011542639.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1568
    CEP170_C; CEP170 C-terminus

  20. XM_011544334.4 → XP_011542636.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542636.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1578
    CEP170_C; CEP170 C-terminus

  21. XM_011544335.4 → XP_011542637.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542637.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1578
    CEP170_C; CEP170 C-terminus

  22. XM_011544336.3 → XP_011542638.1  centrosomal protein of 170 kDa isoform X1

    See identical proteins and their annotated locations for XP_011542638.1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1578
    CEP170_C; CEP170 C-terminus

  23. XM_017002932.2 → XP_016858421.1  centrosomal protein of 170 kDa isoform X1

    UniProtKB/TrEMBL
    H0Y2V6
    Conserved Domains (4) summary
    pfam09528
    Location:466 → 916
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG1716
    Location:12 → 90
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:5 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam15308
    Location:873 → 1578
    CEP170_C; CEP170 C-terminus

  24. XM_047435495.1 → XP_047291451.1  centrosomal protein of 170 kDa isoform X1

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187519.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    136536..267572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328636.1 → XP_054184611.1  centrosomal protein of 170 kDa isoform X1

  2. XM_054328633.1 → XP_054184608.1  centrosomal protein of 170 kDa isoform X1

  3. XM_054328653.1 → XP_054184628.1  centrosomal protein of 170 kDa isoform X18

  4. XM_054328651.1 → XP_054184626.1  centrosomal protein of 170 kDa isoform X16

  5. XM_054328647.1 → XP_054184622.1  centrosomal protein of 170 kDa isoform X12

  6. XM_054328652.1 → XP_054184627.1  centrosomal protein of 170 kDa isoform X17

  7. XM_054328650.1 → XP_054184625.1  centrosomal protein of 170 kDa isoform X15

  8. XM_054328649.1 → XP_054184624.1  centrosomal protein of 170 kDa isoform X14

  9. XM_054328648.1 → XP_054184623.1  centrosomal protein of 170 kDa isoform X13

  10. XM_054328646.1 → XP_054184621.1  centrosomal protein of 170 kDa isoform X11

  11. XM_054328645.1 → XP_054184620.1  centrosomal protein of 170 kDa isoform X10

  12. XM_054328644.1 → XP_054184619.1  centrosomal protein of 170 kDa isoform X9

  13. XM_054328643.1 → XP_054184618.1  centrosomal protein of 170 kDa isoform X8

  14. XM_054328641.1 → XP_054184616.1  centrosomal protein of 170 kDa isoform X6

  15. XM_054328642.1 → XP_054184617.1  centrosomal protein of 170 kDa isoform X7

  16. XM_054328640.1 → XP_054184615.1  centrosomal protein of 170 kDa isoform X5

  17. XM_054328639.1 → XP_054184614.1  centrosomal protein of 170 kDa isoform X4

  18. XM_054328638.1 → XP_054184613.1  centrosomal protein of 170 kDa isoform X3

  19. XM_054328637.1 → XP_054184612.1  centrosomal protein of 170 kDa isoform X2

  20. XM_054328631.1 → XP_054184606.1  centrosomal protein of 170 kDa isoform X1

  21. XM_054328632.1 → XP_054184607.1  centrosomal protein of 170 kDa isoform X1

  22. XM_054328634.1 → XP_054184609.1  centrosomal protein of 170 kDa isoform X1

  23. XM_054328635.1 → XP_054184610.1  centrosomal protein of 170 kDa isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    242535446..242666489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339854.1 → XP_054195829.1  centrosomal protein of 170 kDa isoform X1

  2. XM_054339851.1 → XP_054195826.1  centrosomal protein of 170 kDa isoform X1

  3. XM_054339871.1 → XP_054195846.1  centrosomal protein of 170 kDa isoform X18

  4. XM_054339869.1 → XP_054195844.1  centrosomal protein of 170 kDa isoform X16

  5. XM_054339865.1 → XP_054195840.1  centrosomal protein of 170 kDa isoform X12

  6. XM_054339870.1 → XP_054195845.1  centrosomal protein of 170 kDa isoform X17

  7. XM_054339868.1 → XP_054195843.1  centrosomal protein of 170 kDa isoform X15

  8. XM_054339867.1 → XP_054195842.1  centrosomal protein of 170 kDa isoform X14

  9. XM_054339866.1 → XP_054195841.1  centrosomal protein of 170 kDa isoform X13

  10. XM_054339864.1 → XP_054195839.1  centrosomal protein of 170 kDa isoform X11

  11. XM_054339863.1 → XP_054195838.1  centrosomal protein of 170 kDa isoform X10

  12. XM_054339862.1 → XP_054195837.1  centrosomal protein of 170 kDa isoform X9

  13. XM_054339861.1 → XP_054195836.1  centrosomal protein of 170 kDa isoform X8

  14. XM_054339859.1 → XP_054195834.1  centrosomal protein of 170 kDa isoform X6

  15. XM_054339860.1 → XP_054195835.1  centrosomal protein of 170 kDa isoform X7

  16. XM_054339858.1 → XP_054195833.1  centrosomal protein of 170 kDa isoform X5

  17. XM_054339857.1 → XP_054195832.1  centrosomal protein of 170 kDa isoform X4

  18. XM_054339856.1 → XP_054195831.1  centrosomal protein of 170 kDa isoform X3

  19. XM_054339855.1 → XP_054195830.1  centrosomal protein of 170 kDa isoform X2

  20. XM_054339849.1 → XP_054195824.1  centrosomal protein of 170 kDa isoform X1

  21. XM_054339850.1 → XP_054195825.1  centrosomal protein of 170 kDa isoform X1

  22. XM_054339852.1 → XP_054195827.1  centrosomal protein of 170 kDa isoform X1

  23. XM_054339853.1 → XP_054195828.1  centrosomal protein of 170 kDa isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SW79.1 GenPept UniProtKB/Swiss-Prot:Q5SW79

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