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LRRC37A leucine rich repeat containing 37A [ Homo sapiens (human) ]

Gene ID: 9884, updated on 27-Nov-2024

Summary

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Official Symbol
LRRC37Aprovided by HGNC
Official Full Name
leucine rich repeat containing 37Aprovided by HGNC
Primary source
HGNC:HGNC:29069
See related
Ensembl:ENSG00000176681 MIM:616555; AllianceGenome:HGNC:29069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC37; LRRC37A1
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 14.7), bone marrow (RPKM 4.6) and 23 other tissues See more
Orthologs
all
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Genomic context

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See LRRC37A in Genome Data Viewer
Location:
17q21.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (46248044..46337794)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (47110074..47199790)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44372497..44415160)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene KANSL1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44337043-44337589 Neighboring gene chromosome 17 open reading frame 58 pseudogene Neighboring gene mitogen-activated protein kinase 8 interacting protein 1 pseudogene 1 Neighboring gene uncharacterized LOC124904014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:44361168-44362367 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:44365530-44366030 Neighboring gene DND microRNA-mediated repression inhibitor 1 pseudogene 2 Neighboring gene ARF like GTPase 17B Neighboring gene RNA, 7SL, cytoplasmic 656, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7330 Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide-sensitive factor pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:44569061-44569562 Neighboring gene ARF like GTPase 17A Neighboring gene RDM1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural evolution of the BRCA1 genomic region in primates. Jin H, et al. Genomics, 2004 Dec. PMID 15533724
  2. Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region. Bekpen C, et al. Genome Res, 2012 Jun. PMID 22419166, Free PMC Article
  3. Evolutionary dynamism of the primate LRRC37 gene family. Giannuzzi G, et al. Genome Res, 2013 Jan. PMID 23064749, Free PMC Article
  4. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). Hart AB, et al. PLoS One, 2012. PMID 22952603, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Feb 28. PMID 9628581

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0563, DKFZp686N1231

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 37A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014834.4 → NP_055649.4  leucine-rich repeat-containing protein 37A precursor

    See identical proteins and their annotated locations for NP_055649.4

    Status: VALIDATED

    Source sequence(s)
    AC005829, AC217777
    Consensus CDS
    CCDS11504.2
    UniProtKB/Swiss-Prot
    A6NMS7, Q68DY2, Q8IWC7
    UniProtKB/TrEMBL
    A0A0G2JNC9
    Related
    ENSP00000326324.5, ENST00000320254.5
    Conserved Domains (5) summary
    sd00031
    Location:891 → 914
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:892 → 929
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:892 → 949
    LRR_8; Leucine rich repeat
    pfam14914
    Location:1468 → 1613
    LRRC37AB_C; LRRC37A/B like protein 1 C-terminal domain
    pfam15779
    Location:561 → 629
    LRRC37; Leucine-rich repeat-containing protein 37 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    46248044..46337794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437205.1 → XP_047293161.1  leucine-rich repeat-containing protein 37A isoform X10

  2. XM_047437200.1 → XP_047293156.1  leucine-rich repeat-containing protein 37A isoform X4

  3. XM_047437206.1 → XP_047293162.1  leucine-rich repeat-containing protein 37A isoform X9

    UniProtKB/TrEMBL
    E9PP10
    Related
    ENSP00000437021.1, ENST00000496930.5

  4. XM_047437196.1 → XP_047293152.1  leucine-rich repeat-containing protein 37A isoform X1

  5. XM_047437197.1 → XP_047293153.1  leucine-rich repeat-containing protein 37A isoform X2

  6. XM_047437198.1 → XP_047293154.1  leucine-rich repeat-containing protein 37A isoform X3

  7. XM_047437199.1 → XP_047293155.1  leucine-rich repeat-containing protein 37A isoform X5

  8. XM_047437201.1 → XP_047293157.1  leucine-rich repeat-containing protein 37A isoform X6

  9. XM_047437202.1 → XP_047293158.1  leucine-rich repeat-containing protein 37A isoform X7

  10. XM_047437204.1 → XP_047293160.1  leucine-rich repeat-containing protein 37A isoform X8

  11. XM_047437203.1 → XP_047293159.1  leucine-rich repeat-containing protein 37A isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    413631..539475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328599.1 → XP_054184574.1  leucine-rich repeat-containing protein 37A isoform X10

  2. XM_054328591.1 → XP_054184566.1  leucine-rich repeat-containing protein 37A isoform X12

  3. XM_054328590.1 → XP_054184565.1  leucine-rich repeat-containing protein 37A isoform X12

  4. XM_054328600.1 → XP_054184575.1  leucine-rich repeat-containing protein 37A isoform X9

    UniProtKB/TrEMBL
    A0A0G2JQV0

  5. XM_054328594.1 → XP_054184569.1  leucine-rich repeat-containing protein 37A isoform X4

  6. XM_054328592.1 → XP_054184567.1  leucine-rich repeat-containing protein 37A isoform X13

  7. XM_054328593.1 → XP_054184568.1  leucine-rich repeat-containing protein 37A isoform X5

  8. XM_054328589.1 → XP_054184564.1  leucine-rich repeat-containing protein 37A isoform X3

  9. XM_054328588.1 → XP_054184563.1  leucine-rich repeat-containing protein 37A isoform X2

  10. XM_054328587.1 → XP_054184562.1  leucine-rich repeat-containing protein 37A isoform X1

  11. XM_054328598.1 → XP_054184573.1  leucine-rich repeat-containing protein 37A isoform X14

  12. XM_054328597.1 → XP_054184572.1  leucine-rich repeat-containing protein 37A isoform X8

  13. XM_054328595.1 → XP_054184570.1  leucine-rich repeat-containing protein 37A isoform X7

  14. XM_054328596.1 → XP_054184571.1  leucine-rich repeat-containing protein 37A isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    47110074..47199790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318056.1 → XP_054174031.1  leucine-rich repeat-containing protein 37A isoform X10

  2. XM_054318054.1 → XP_054174029.1  leucine-rich repeat-containing protein 37A isoform X16

  3. XM_054318045.1 → XP_054174020.1  leucine-rich repeat-containing protein 37A isoform X15

  4. XM_054318055.1 → XP_054174030.1  leucine-rich repeat-containing protein 37A isoform X9

  5. XM_054318049.1 → XP_054174024.1  leucine-rich repeat-containing protein 37A isoform X4

  6. XM_054318046.1 → XP_054174021.1  leucine-rich repeat-containing protein 37A isoform X1

  7. XM_054318047.1 → XP_054174022.1  leucine-rich repeat-containing protein 37A isoform X2

  8. XM_054318048.1 → XP_054174023.1  leucine-rich repeat-containing protein 37A isoform X3

  9. XM_054318050.1 → XP_054174025.1  leucine-rich repeat-containing protein 37A isoform X5

  10. XM_054318051.1 → XP_054174026.1  leucine-rich repeat-containing protein 37A isoform X6

  11. XM_054318053.1 → XP_054174028.1  leucine-rich repeat-containing protein 37A isoform X8

  12. XM_054318052.1 → XP_054174027.1  leucine-rich repeat-containing protein 37A isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NMS7.3 GenPept UniProtKB/Swiss-Prot:A6NMS7

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