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Ssx2ip SSX family member 2 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 99167, updated on 27-Nov-2024

Summary

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Official Symbol
Ssx2ipprovided by MGI
Official Full Name
SSX family member 2 interacting proteinprovided by MGI
Primary source
MGI:MGI:2139150
See related
Ensembl:ENSMUSG00000036825 AllianceGenome:MGI:2139150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adip
Summary
Predicted to enable protein domain specific binding activity. Acts upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in cell leading edge; centriolar satellite; and ciliary basal body. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 30.6), liver E14 (RPKM 23.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ssx2ip in Genome Data Viewer
Location:
3 H2; 3 71.03 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146110397..146145899)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146404642..146440144)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10636 Neighboring gene STARR-seq mESC enhancer starr_09222 Neighboring gene predicted gene, 22078 Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene G protein subunit gamma 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. Kurtulmus B, et al. J Cell Sci, 2016 Feb 1. PMID 26675238
  2. OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. Wang B, et al. EMBO Rep, 2021 Jul 5. PMID 33987909, Free PMC Article
  3. Afadin- and alpha-actinin-binding protein ADIP directly binds beta'-COP, a subunit of the coatomer complex. Asada M, et al. Biochem Biophys Res Commun, 2004 Aug 20. PMID 15358183
  4. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone. Klinger M, et al. Mol Biol Cell, 2014 Feb. PMID 24356449, Free PMC Article
  5. ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. Asada M, et al. J Biol Chem, 2003 Feb 7. PMID 12446711

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
    Title: OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.
  2. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
    Title: The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
  3. The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac.
    Title: Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.
  4. localization at cell-cell adherens junctions
    Title: ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport involved in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
afadin- and alpha-actinin-binding protein
Names
SSX 2 interacting protein
afadin DIL domain-interacting protein
synovial sarcoma, X 2 interacting protein
synovial sarcoma, X breakpoint 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253768.2 → NP_001240697.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240697.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK049080, AK077112, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/TrEMBL
    A0A0R4J1A9, Q69ZV4
    Related
    ENSMUSP00000101755.2, ENSMUST00000106149.8
    Conserved Domains (1) summary
    pfam11559
    Location:63 → 214
    ADIP; Afadin- and alpha -actinin-Binding

  2. NM_001253769.2 → NP_001240698.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240698.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK043865, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/TrEMBL
    A0A0R4J1A9, Q69ZV4
    Related
    ENSMUSP00000101757.2, ENSMUST00000106151.8
    Conserved Domains (1) summary
    pfam11559
    Location:63 → 214
    ADIP; Afadin- and alpha -actinin-Binding

  3. NM_001253770.2 → NP_001240699.1  afadin- and alpha-actinin-binding protein isoform b

    See identical proteins and their annotated locations for NP_001240699.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK031356, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS57260.1
    UniProtKB/TrEMBL
    A0A0R4J1A9, Q69ZV4
    Related
    ENSMUSP00000045663.5, ENSMUST00000039021.11
    Conserved Domains (1) summary
    pfam11559
    Location:63 → 214
    ADIP; Afadin- and alpha -actinin-Binding

  4. NM_001355661.1 → NP_001342590.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    Consensus CDS
    CCDS38665.1
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
    UniProtKB/TrEMBL
    Q69ZV4
    Conserved Domains (2) summary
    pfam11559
    Location:63 → 214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140 → 301
    DUF5401; Family of unknown function (DUF5401)

  5. NM_001411104.1 → NP_001398033.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

  6. NM_001411105.1 → NP_001398034.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

  7. NM_001411107.1 → NP_001398036.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

  8. NM_001411108.1 → NP_001398037.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

  9. NM_001411109.1 → NP_001398038.1  afadin- and alpha-actinin-binding protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66

  10. NM_001411110.1 → NP_001398039.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9

  11. NM_001411114.1 → NP_001398043.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9

  12. NM_001411115.1 → NP_001398044.1  afadin- and alpha-actinin-binding protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124987
    UniProtKB/TrEMBL
    A0A0R4J1A9

  13. NM_001411116.1 → NP_001398045.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987

  14. NM_001411117.1 → NP_001398046.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987

  15. NM_001411118.1 → NP_001398047.1  afadin- and alpha-actinin-binding protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC124987

  16. NM_001411119.1 → NP_001398048.1  afadin- and alpha-actinin-binding protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC124987

  17. NM_001411120.1 → NP_001398049.1  afadin- and alpha-actinin-binding protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AC124987

  18. NM_001411121.1 → NP_001398050.1  afadin- and alpha-actinin-binding protein isoform e

    Status: VALIDATED

    Source sequence(s)
    AC124987

  19. NM_138744.4 → NP_620083.1  afadin- and alpha-actinin-binding protein isoform a

    See identical proteins and their annotated locations for NP_620083.1

    Status: VALIDATED

    Source sequence(s)
    AC124987, AK049080, AK173064, BE945817
    Consensus CDS
    CCDS38665.1
    UniProtKB/Swiss-Prot
    Q8BG59, Q8C7X0, Q8K2F7, Q8VC66
    UniProtKB/TrEMBL
    Q69ZV4
    Related
    ENSMUSP00000101759.3, ENSMUST00000106153.9
    Conserved Domains (2) summary
    pfam11559
    Location:63 → 214
    ADIP; Afadin- and alpha -actinin-Binding
    pfam17380
    Location:140 → 301
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    146110397..146145899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC66.1 GenPept UniProtKB/Swiss-Prot:Q8VC66

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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