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    Serpinb1-ps1 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene [ Mus musculus (house mouse) ]

    Gene ID: 282665, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Serpinb1-ps1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogeneprovided by MGI
    Primary source
    MGI:MGI:2445366
    See related
    Ensembl:ENSMUSG00000081433 AllianceGenome:MGI:2445366
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EID; ovalbumin
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    Genomic context

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    See Serpinb1-ps1 in Genome Data Viewer
    Location:
    13 A3.2; 13 13.76 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (33043931..33047161, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32859948..32863178, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Werner helicase interacting protein 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a Neighboring gene predicted gene, 35899 Neighboring gene nonconserved acetylation island sequence M71 enhancer Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1c Neighboring gene SCAN domain containing 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection. Gong D, et al. J Infect Dis, 2011 Aug 15. PMID 21791661, Free PMC Article
    2. SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice. Cremona TP, et al. Am J Physiol Lung Cell Mol Physiol, 2013 Dec. PMID 24163143
    3. SerpinB1 protects the mature neutrophil reserve in the bone marrow. Benarafa C, et al. J Leukoc Biol, 2011 Jul. PMID 21248149, Free PMC Article
    4. The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. Benarafa C, et al. J Exp Med, 2007 Aug 6. PMID 17664292, Free PMC Article
    5. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). Benarafa C, et al. J Biol Chem, 2002 Nov 1. PMID 12189154

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. serpinB1 are similarly potent inhibitors of neutrophil proteases, serpinB1 deficiency is not associated with more severe emphysema
      Title: SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice.
    2. The study highlights the critical role of serpinB1 in mitigating inflammation and restricting pro-inflammatory cytokine production in influenza infection.
      Title: Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection.
    3. serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses.
      Title: SerpinB1 protects the mature neutrophil reserve in the bone marrow.
    4. serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
      Title: The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
    5. cDNA cloning, gene structure and biological characterization homologous to human MNEI
      Title: Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1, pseudogene
    • serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1a pseudogene
    • serine (or cysteine) proteinase inhibitor, clade B, member 1, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_003057.2 

      Range
      101..3331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      33043931..33047161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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