Calhm3 calcium homeostasis modulator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calhm3provided by MGI
Official Full Name: calcium homeostasis modulator 3provided by MGI
Primary source: MGI:MGI:3645665
See related: Ensembl:ENSMUSG00000094219 AllianceGenome:MGI:3645665
Gene type: pseudo
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG240669
Summary: Enables voltage-gated monoatomic ion channel activity. Involved in ATP export; protein heterooligomerization; and sensory perception of taste. Located in basolateral plasma membrane. Is expressed in circumvallate papillae and forebrain. Orthologous to human CALHM3 (calcium homeostasis modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 19 C3; 19 39.37 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47140138..47146203, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47151699..47157764, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
Title: CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells.
CALHM3, together with CALHM1, is essential to form fast voltage-gated ATP-release channesl in taste bud cells required for taste.
Title: CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Markers

D19Mit10 (e-PCR), detects polymorphism
- UniSTS:128314

D0M19Mit8 (e-PCR)
- UniSTS:128419

D19Mit8 (e-PCR), detects polymorphism
- UniSTS:128419

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IDA Inferred from Direct Assay more info	PubMed
involved_in ATP transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.