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    ROCK1P1 Rho associated coiled-coil containing protein kinase 1 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 727758, updated on 22-Oct-2024

    Summary

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    Official Symbol
    ROCK1P1provided by HGNC
    Official Full Name
    Rho associated coiled-coil containing protein kinase 1 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:37832
    See related
    Ensembl:ENSG00000290877 AllianceGenome:HGNC:37832
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROCK1P
    Expression
    Ubiquitous expression in testis (RPKM 12.3), bone marrow (RPKM 9.6) and 25 other tissues See more
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    Genomic context

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    See ROCK1P1 in Genome Data Viewer
    Location:
    18p11.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (109065..122340)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (262855..276133)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (109065..122340)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene tubulin beta 8B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:78692-79192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:79193-79693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:81490-82403 Neighboring gene Sharpr-MPRA regulatory region 10972 Neighboring gene IL9R pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:106915-107598 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:107891-108680 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:108681-109468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:109469-110257 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:110258-111045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9235 Neighboring gene microRNA 8078 Neighboring gene uncharacterized LOC105371951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9237 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:185973-186474 Neighboring gene THO complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. Montefusco MC, et al. BMC Genet, 2010 Apr 14. PMID 20398283, Free PMC Article
    2. Transcriptional fates of human-specific segmental duplications in brain. Dougherty ML, et al. Genome Res, 2018 Oct. PMID 30228200, Free PMC Article
    3. Genome-wide association study of chronic periodontitis in a general German population. Teumer A, et al. J Clin Periodontol, 2013 Nov. PMID 24024966
    4. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chronic periodontitis in a general German population.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_033770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP001005, BC041849
      Related
      ENST00000608049.5

    2. NR_160777.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      MH721915
      Related
      ENST00000576266.7

    3. NR_160778.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      MH721914, MH721915
      Related
      ENST00000693583.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      109065..122340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      262855..276133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials