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NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (Francisella tularensis subsp. holarctica str. LVS; Francisella tularensis subsp. holarctica strain LVS). [ Francisella tularensis subsp. holarctica LVS ]

Gene ID: 9797201, updated on 13-Nov-2024

Summary

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Gene symbol
NEWENTRY
Gene description
Record to support submission of GeneRIFs for a gene not in Gene (Francisella tularensis subsp. holarctica str. LVS; Francisella tularensis subsp. holarctica strain LVS).
Gene type
other
Organism
Francisella tularensis subsp. holarctica LVS
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Thiotrichales; Francisellaceae; Francisella
Also known as
NEWENTRY
NEW
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A study of innate immune kinetics reveals a role for a chloride transporter in a virulent Francisella tularensis type B strain.
    Title: A study of innate immune kinetics reveals a role for a chloride transporter in a virulent Francisella tularensis type B strain.
  2. OpiA, a Type Six Secretion System Substrate, Localizes to the Cell Pole and Plays a Role in Bacterial Growth and Viability in Francisella tularensis LVS.
    Title: OpiA, a Type Six Secretion System Substrate, Localizes to the Cell Pole and Plays a Role in Bacterial Growth and Viability in Francisella tularensis LVS.
  3. FupA/B deletion promoted increased secretion of outer membrane vesicles. [FupA]
    Title: Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation.
  4. IglE helps to prevent dynein- and MTOC-mediated intracellular trafficking in host cells to inhibit the transport of F. novicida toward lysosomes. [IglE]
    Title: Expression of Francisella pathogenicity island protein intracellular growth locus E (IglE) in mammalian cells is involved in intracellular trafficking, possibly through microtubule organizing center.
  5. Mass spectrometry analysis revealed a similar substrate cleavage pattern between the bacterial and human Lon variants, which was exemplified by predominant representation of leucine, alanine, and other hydrophobic amino acids at the P(-1) site within the substrates. [Lon]
    Title: Multiple domains of bacterial and human Lon proteases define substrate selectivity.
  6. Our findings identify polyphosphate kinase as a novel negative regulator of virulence gene expression in F. tularensis [Polyphosphate Kinase].
    Title: Polyphosphate Kinase Antagonizes Virulence Gene Expression in Francisella tularensis.
  7. study highlights the importance of IglE in F. tularensis pathogenicity, and the contribution of the N-terminus to its funmction [IglE]
    Title: A mutagenesis-based approach identifies amino acids in the N-terminal part of Francisella tularensis IglE that critically control Type VI system-mediated secretion.
  8. These lines of evidence strongly suggest that the FtlA lipase promotes F. tularensis adhesion and internalization by modifying bacterial and/or host molecule(s) when it is secreted as a component of outer membrane vesicles [FtlA]
    Title: Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS.
  9. The data suggest that IglG is a PAAR-like protein acting as a bi-modal protein that may connect the tip of the Francisella T6SS with a putative l type VI secretion system (T6SS) effector, IglF[IglG]
    Title: Francisella tularensis IglG Belongs to a Novel Family of PAAR-Like T6SS Proteins and Harbors a Unique N-terminal Extension Required for Virulence.
  10. In accordance with the hypothesis, DeltaoxyR/DeltakatG was distinctly more susceptible than DeltaoxyR and DeltakatG to H2O2, ONOO(-) and O2(-), moreover, it hardly grew in mouse-derived BMDM or in mice, whereas DeltakatG and DeltaoxyR grew as well as parental Frecisella tularensis LVS.[oxyR, katG]
    Title: Lack of OxyR and KatG Results in Extreme Susceptibility of Francisella tularensis LVS to Oxidative Stress and Marked Attenuation In vivo.
Submit: New GeneRIF Correction See all GeneRIFs (13)

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