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    NPM2 nucleophosmin/nucleoplasmin 2 [ Homo sapiens (human) ]

    Gene ID: 10361, updated on 10-Dec-2024

    Summary

    Official Symbol
    NPM2provided by HGNC
    Official Full Name
    nucleophosmin/nucleoplasmin 2provided by HGNC
    Primary source
    HGNC:HGNC:7930
    See related
    Ensembl:ENSG00000158806 MIM:608073; AllianceGenome:HGNC:7930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thyroid (RPKM 3.7), brain (RPKM 3.7) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NPM2 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22024134..22036897)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22298091..22310854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21881645..21894408)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18974 Neighboring gene docking protein 2 Neighboring gene exportin 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21802075-21802708 Neighboring gene uncharacterized LOC124901903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21806752-21807252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27071 Neighboring gene VISTA enhancer hs783 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21867514-21868173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21868174-21868832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21880733-21881446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21881447-21882159 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21893938-21894622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21894623-21895307 Neighboring gene VISTA enhancer hs782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene VISTA enhancer hs781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21908959-21909751 Neighboring gene fibroblast growth factor 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21915443-21916404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21917368-21918329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18975 Neighboring gene dematin actin binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ45699, MGC78655

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286680.2NP_001273609.1  nucleoplasmin-2 isoform 1

      See identical proteins and their annotated locations for NP_001273609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AY262113, DB262972
      Consensus CDS
      CCDS6018.1
      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8
      Related
      ENSP00000427741.1, ENST00000518119.6
      Conserved Domains (1) summary
      pfam03066
      Location:18119
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    2. NM_001286681.2NP_001273610.1  nucleoplasmin-2 isoform 2

      See identical proteins and their annotated locations for NP_001273610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC091171
      Consensus CDS
      CCDS75703.1
      UniProtKB/TrEMBL
      E5RFQ8
      Related
      ENSP00000370941.5, ENST00000381530.9
      Conserved Domains (1) summary
      pfam03066
      Location:18119
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    3. NM_001413113.1NP_001400042.1  nucleoplasmin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091171
      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8
    4. NM_001413114.1NP_001400043.1  nucleoplasmin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC091171
    5. NM_001413115.1NP_001400044.1  nucleoplasmin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091171
    6. NM_001413116.1NP_001400045.1  nucleoplasmin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC091171
      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8
      Related
      ENSP00000381032.1, ENST00000397940.5
    7. NM_001413117.1NP_001400046.1  nucleoplasmin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC091171
    8. NM_001413118.1NP_001400047.1  nucleoplasmin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC091171
    9. NM_001413119.1NP_001400048.1  nucleoplasmin-2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC091171
    10. NM_001413120.1NP_001400049.1  nucleoplasmin-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC091171
    11. NM_001413121.1NP_001400050.1  nucleoplasmin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091171
      UniProtKB/TrEMBL
      E5RFQ8
      Related
      ENSP00000481018.1, ENST00000615914.1
    12. NM_182795.2NP_877724.1  nucleoplasmin-2 isoform 1

      See identical proteins and their annotated locations for NP_877724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC091171
      Consensus CDS
      CCDS6018.1
      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8
      Conserved Domains (1) summary
      pfam03066
      Location:18119
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

    RNA

    1. NR_182112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      22024134..22036897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421220.1XP_047277176.1  nucleoplasmin-2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8
      Related
      ENSP00000289820.6, ENST00000289820.10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      22298091..22310854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359535.1XP_054215510.1  nucleoplasmin-2 isoform X1

      UniProtKB/Swiss-Prot
      B3KSU0, D3DSQ8, Q6NVH6, Q86SE8