Zfpm2 zinc finger protein, multitype 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfpm2provided by MGI
Official Full Name: zinc finger protein, multitype 2provided by MGI
Primary source: MGI:MGI:1334444
See related: Ensembl:ENSMUSG00000022306 AllianceGenome:MGI:1334444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FOG2; FOG-2; B330005D23Rik
Summary: Enables transcription corepressor activity. Involved in several processes, including negative regulation of female gonad development; positive regulation of cardiac muscle cell proliferation; and positive regulation of male gonad development. Acts upstream of or within several processes, including circulatory system development; in utero embryonic development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study congenital diaphragmatic hernia; tetralogy of Fallot; and tricuspid atresia. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 6.0), CNS E14 (RPKM 3.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.74 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (40518438..40967988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (40655042..41104592)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Title: A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis.
Title: The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis.
Fog2Rb-/Rb- mice are resistant to obesity and present abnormal WAT/BAT conversion.
Title: The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis.
identified key controls over corticothalamic projection neurons (CThPN) development and identify Fog2 as a critical control over CThPN diversity
Title: Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity.
FOG2 liver-specific knockout mice they exhibit enhanced insulin sensitivity and elevated hepatic TG accumulation, which were also reversed by Ad-PPARalpha. The results demonstrate a novel function of hepatic FOG2 in insulin sensitivity and lipid metabolism through PPARalpha.
Title: A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARα.
Hypoxia-induced microRNA-429 promotes differentiation of osteoblastic cells by mediating ZFPM2 expression.
Title: Hypoxia-Induced MicroRNA-429 Promotes Differentiation of MC3T3-E1 Osteoblastic Cells by Mediating ZFPM2 Expression.
MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression
Title: MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression.
Results indicate that FOG-2/NuRD interaction is required for cardiomyocyte proliferation.
Title: FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development.
ATOH8, GATA4, and FOG2 associate in a single complex
Title: The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.
regulation of ovarian differentiation is dependent upon GATA4 but not FOG2
Title: The transcription factor GATA4 is required for follicular development and normal ovarian function.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zfpm2 (e-PCR), detects polymorphism
- UniSTS:464703

Mbtd1 (e-PCR), detects polymorphism
- UniSTS:498269

PMC303372P1 (e-PCR)
- UniSTS:272518

Zfpm2 (e-PCR), detects polymorphism
- UniSTS:515990

Zfpm2 (e-PCR), detects polymorphism
- UniSTS:531387

Zfpm2 (e-PCR), detects polymorphism
- UniSTS:502737

Zfpm2 (e-PCR), detects polymorphism
- UniSTS:502738

06.MMHAP86FLB3.seq (e-PCR)
- UniSTS:122871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitral valve formation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macromolecule biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in right ventricular cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in right ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tricuspid valve formation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within vasculogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein ZFPM2

Names: Friend of GATA 2; friend of GATA protein 2; friend of GATA-1 2; friend of GATA-2; mFOG-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356998.1 → NP_001343927.1 zinc finger protein ZFPM2 isoform 2

Status: VALIDATED

Source sequence(s)

AC101996, AC102004, AC158556, AC163008

UniProtKB/TrEMBL

A5HE91

Related

ENSMUSP00000155094.2, ENSMUST00000230319.2

Conserved Domains (2) summary

sd00017
Location:248 → 267

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:245 → 349

zf-C2H2_8; C2H2-type zinc ribbon
NM_011766.5 → NP_035896.1 zinc finger protein ZFPM2 isoform 1

See identical proteins and their annotated locations for NP_035896.1

Status: VALIDATED

Source sequence(s)

AC101996, AC102004, AC158556, AC163008

Consensus CDS

CCDS27447.1

UniProtKB/Swiss-Prot

Q8CCH7, Q9Z0F2

UniProtKB/TrEMBL

A5HE91

Related

ENSMUSP00000051335.5, ENSMUST00000053467.6

Conserved Domains (2) summary

sd00017
Location:301 → 320

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam15909
Location:298 → 388

zf-C2H2_8; C2H2-type zinc ribbon