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    Spink10 serine peptidase inhibitor, Kazal type 10 [ Mus musculus (house mouse) ]

    Gene ID: 328971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spink10provided by MGI
    Official Full Name
    serine peptidase inhibitor, Kazal type 10provided by MGI
    Primary source
    MGI:MGI:3584533
    See related
    Ensembl:ENSMUSG00000044176 AllianceGenome:MGI:3584533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230091H23Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 10.9) and testis adult (RPKM 0.8) See more
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    Genomic context

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    See Spink10 in Genome Data Viewer
    Location:
    18 E1; 18 35.22 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62681982..62797412)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62548873..62664341)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide pseudogene Neighboring gene STARR-seq mESC enhancer starr_44778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62879723-62879876 Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel epididymal protease inhibitors with Kazal or WAP family domain. Jalkanen J, et al. Biochem Biophys Res Commun, 2006 Oct 13. PMID 16930550
    2. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177829.3 → NP_808497.1  serine protease inhibitor Kazal-type 10

      See identical proteins and their annotated locations for NP_808497.1

      Status: VALIDATED

      Source sequence(s)
      AK039062, AV380905
      Consensus CDS
      CCDS29293.1
      UniProtKB/Swiss-Prot
      Q8CAC8
      Related
      ENSMUSP00000062976.5, ENSMUST00000055725.12
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      62681982..62797412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161183.1 → XP_036017076.1  serine protease inhibitor Kazal-type 10 isoform X2

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    2. XM_036161184.1 → XP_036017077.1  serine protease inhibitor Kazal-type 10 isoform X2

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    3. XM_030250514.2 → XP_030106374.1  serine protease inhibitor Kazal-type 10 isoform X2

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    4. XM_006526029.5 → XP_006526092.1  serine protease inhibitor Kazal-type 10 isoform X1

      Conserved Domains (2) summary
      pfam00050
      Location:117 → 167
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:40 → 74
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    5. XM_006526034.5 → XP_006526097.1  serine protease inhibitor Kazal-type 10 isoform X2

      See identical proteins and their annotated locations for XP_006526097.1

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    6. XM_006526033.5 → XP_006526096.1  serine protease inhibitor Kazal-type 10 isoform X2

      See identical proteins and their annotated locations for XP_006526096.1

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    7. XM_006526035.5 → XP_006526098.1  serine protease inhibitor Kazal-type 10 isoform X2

      See identical proteins and their annotated locations for XP_006526098.1

      UniProtKB/Swiss-Prot
      Q8CAC8
      Conserved Domains (2) summary
      pfam00050
      Location:112 → 162
      Kazal_1; Kazal-type serine protease inhibitor domain
      cl00097
      Location:35 → 69
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAC8.1 GenPept UniProtKB/Swiss-Prot:Q8CAC8

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