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    Fam136a family with sequence similarity 136, member A [ Mus musculus (house mouse) ]

    Gene ID: 66488, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fam136aprovided by MGI
    Official Full Name
    family with sequence similarity 136, member Aprovided by MGI
    Primary source
    MGI:MGI:1913738
    See related
    Ensembl:ENSMUSG00000057497 AllianceGenome:MGI:1913738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hyccin; 2010309E21Rik
    Summary
    Located in mitochondrion. Is expressed in several structures, including alimentary system; orbito-sphenoid; renal cortex; respiratory system; and submandibular gland primordium. Orthologous to human FAM136A (family with sequence similarity 136 member A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 32.7), liver E18 (RPKM 18.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam136a in Genome Data Viewer
    Location:
    6 D1; 6 37.69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86342453..86347040)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86365471..86370058)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene katanin p80 (WD40-containing) subunit B 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2792 Neighboring gene STARR-positive B cell enhancer ABC_E4839 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene predicted gene, 52865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease. Babu V, et al. Eur J Neurosci, 2023 Aug. PMID 37461313
    2. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Fancy SP, et al. Genes Dev, 2009 Jul 1. PMID 19515974, Free PMC Article
    3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117903

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    protein FAM136A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368363.1 → NP_001355292.1  protein FAM136A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155947

    2. NM_025591.3 → NP_079867.1  protein FAM136A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155947
      Consensus CDS
      CCDS20309.1
      UniProtKB/Swiss-Prot
      Q91YY1, Q9CR98
      Related
      ENSMUSP00000071426.8, ENSMUST00000071492.9
      Conserved Domains (1) summary
      pfam05811
      Location:5 → 127
      DUF842; Eukaryotic protein of unknown function (DUF842)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86342453..86347040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR98.1 GenPept UniProtKB/Swiss-Prot:Q9CR98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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