Nat8 N-acetyltransferase 8 (GCN5-related) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat8provided by MGI
Official Full Name: N-acetyltransferase 8 (GCN5-related)provided by MGI
Primary source: MGI:MGI:1915646
See related: Ensembl:ENSMUSG00000030004 AllianceGenome:MGI:1915646
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml4; CCNAT; ATase2; 0610037O16Rik
Summary: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Involved in gastrulation with mouth forming second. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 43.2), duodenum adult (RPKM 18.8) and 4 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6 C3; 6 37.49 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85807369..85813839, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85830387..85836857, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that Nat8 is down-regulated in liver ischemia/reperfusion injury and its upregulation prevents it suggesting its protective effect against liver injuries.
Title: The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-S-conjugate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-S-conjugate N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell adhesion	ISA Inferred from Sequence Alignment more info	PubMed
involved_in peptidyl-lysine N6-acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in late recombination nodule	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: N-acetyltransferase 8

Names: N-acetyltransferase 8 (GCN5-related, putative); acetyltransferase 2; camello-like 4; camello-like protein 4; cysteinyl-conjugate N-acetyltransferase; probable N-acetyltransferase CML4

NP_001348989.1

EC 2.3.1.80

NP_075944.1

EC 2.3.1.80

XP_006506599.1

EC 2.3.1.80

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362060.1 → NP_001348989.1 N-acetyltransferase 8

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC161888

Consensus CDS

CCDS20301.1

UniProtKB/Swiss-Prot

Q9JIY7

Conserved Domains (1) summary

pfam00583
Location:91 → 193

Acetyltransf_1; Acetyltransferase (GNAT) family
NM_023455.4 → NP_075944.1 N-acetyltransferase 8

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant (1). Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC161888

Consensus CDS

CCDS20301.1

UniProtKB/Swiss-Prot

Q9JIY7

Related

ENSMUSP00000032073.7, ENSMUST00000032073.7

Conserved Domains (1) summary

pfam00583
Location:91 → 193

Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

85807369..85813839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506536.3 → XP_006506599.1 N-acetyltransferase 8 isoform X1

UniProtKB/Swiss-Prot

Q9JIY7

Conserved Domains (1) summary

pfam00583
Location:91 → 193

Acetyltransf_1; Acetyltransferase (GNAT) family