Nat8f2 N-acetyltransferase 8 (GCN5-related) family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat8f2provided by MGI
Official Full Name: N-acetyltransferase 8 (GCN5-related) family member 2provided by MGI
Primary source: MGI:MGI:2136446
See related: Ensembl:ENSMUSG00000033634 AllianceGenome:MGI:2136446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cml2
Summary: Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to act upstream of or within negative regulation of cell adhesion. Predicted to be located in Golgi apparatus; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in brain; genitourinary system; liver; and respiratory system. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)) and NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward liver adult (RPKM 118.1) See more
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Genomic context

Location:: 6 C3; 6 37.51 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85842404..85846119, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85865422..85869137, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation.
Title: Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-S-conjugate N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum	ISA Inferred from Sequence Alignment more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	ISO Inferred from Sequence Orthology more info
NOT located_in extracellular space	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: N-acetyltransferase family 8 member 2

Names: N-acetyltransferase-like protein CML2; camello-like 2; camello-like protein 2; probable N-acetyltransferase CML2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053096.3 → NP_444326.2 N-acetyltransferase family 8 member 2

See identical proteins and their annotated locations for NP_444326.2

Status: VALIDATED

Source sequence(s)

AC158684, AK050449

Consensus CDS

CCDS20302.1

UniProtKB/Swiss-Prot

Q8C7E5, Q8CHQ9, Q9JIY9

Related

ENSMUSP00000044587.8, ENSMUST00000045008.8

Conserved Domains (2) summary

COG0456
Location:88 → 197

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:112 → 193

Acetyltransf_1; Acetyltransferase (GNAT) family