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    Kif17 kinesin family member 17 [ Mus musculus (house mouse) ]

    Gene ID: 16559, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kif17provided by MGI
    Official Full Name
    kinesin family member 17provided by MGI
    Primary source
    MGI:MGI:1098229
    See related
    Ensembl:ENSMUSG00000028758 AllianceGenome:MGI:1098229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kif17b; mKIAA1405; 5930435E01Rik
    Summary
    Enables microtubule motor activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex. Acts upstream of or within microtubule-based process; protein-containing complex localization; and vesicle-mediated transport. Located in several cellular components, including cytoskeleton; periciliary membrane compartment; and photoreceptor cell cilium. Part of kinesin complex. Is active in postsynapse. Is expressed in central nervous system; retina; and testis. Orthologous to human KIF17 (kinesin family member 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 90.7) and cortex adult (RPKM 5.4) See more
    Orthologs
    NEW
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    Genomic context

    See Kif17 in Genome Data Viewer
    Location:
    4 D3; 4 70.07 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137989562..138029284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138262251..138301973)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heterochromatin protein 1, binding protein 3 Neighboring gene SH2 domain containing 5 Neighboring gene predicted gene, 54278 Neighboring gene STARR-positive B cell enhancer ABC_E8002 Neighboring gene STARR-positive B cell enhancer ABC_E4692 Neighboring gene STARR-seq mESC enhancer starr_11799 Neighboring gene dolichyl-di-phosphooligosaccharide-protein glycotransferase Neighboring gene microRNA 7019 Neighboring gene PTEN induced putative kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Sh2d5

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of kinesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor connecting cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF17
    Names
    N-4 kinesin
    kinesin 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190978.1NP_001177907.1  kinesin-like protein KIF17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks both an in-frame segment in the central coding region and an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK077868, AK083171, AL807249, BI133873
      Consensus CDS
      CCDS57307.1
      UniProtKB/TrEMBL
      A2AM72
      Related
      ENSMUSP00000101447.3, ENSMUST00000105821.3
      Conserved Domains (2) summary
      cl22853
      Location:4335
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:11335
      Kinesin; Kinesin motor domain
    2. NM_010623.4NP_034753.1  kinesin-like protein KIF17 isoform 1

      See identical proteins and their annotated locations for NP_034753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL807249
      Consensus CDS
      CCDS18823.1
      UniProtKB/Swiss-Prot
      A2AM73, Q99PW8
      Related
      ENSMUSP00000030539.4, ENSMUST00000030539.10
      Conserved Domains (3) summary
      cl22853
      Location:4335
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:11335
      Kinesin; Kinesin motor domain
      pfam16214
      Location:9181036
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      137989562..138029284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)