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    Bnipl BCL2/adenovirus E1B 19kD interacting protein like [ Mus musculus (house mouse) ]

    Gene ID: 171388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bniplprovided by MGI
    Official Full Name
    BCL2/adenovirus E1B 19kD interacting protein likeprovided by MGI
    Primary source
    MGI:MGI:2384749
    See related
    Ensembl:ENSMUSG00000028115 AllianceGenome:MGI:2384749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP73; PP753; BNIP-S; BNIPL1; BNIPL2; 1700128A13Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in apoptotic process; negative regulation of cell population proliferation; and regulation of growth rate. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo endoderm; genital tubercle; and urinary system. Orthologous to human BNIPL (BCL2 interacting protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 4.7), bladder adult (RPKM 4.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bnipl in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95148587..95158504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95241276..95252144, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Armfield BA, et al. J Urol, 2016 Oct. PMID 27173853, Free PMC Article
    2. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
    3. The in vivo brain interactome of the amyloid precursor protein. Bai Y, et al. Mol Cell Proteomics, 2008 Jan. PMID 17934213
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC8103

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Names
    BNIP-2 similar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168356.1 → NP_001161828.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC140190, AK142472
      Consensus CDS
      CCDS50988.1
      UniProtKB/TrEMBL
      E9Q8I3, Q3UQG4
      Related
      ENSMUSP00000096468.5, ENSMUST00000098871.11
      Conserved Domains (2) summary
      cd00170
      Location:209 → 264
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
      pfam12496
      Location:50 → 178
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2

    2. NM_134253.2 → NP_599014.2  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC140190
      Consensus CDS
      CCDS17609.2
      UniProtKB/Swiss-Prot
      Q923E3, Q99JU7
      UniProtKB/TrEMBL
      E9QME1
      Related
      ENSMUSP00000102813.3, ENSMUST00000107195.9
      Conserved Domains (1) summary
      cd00170
      Location:194 → 340
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95148587..95158504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252448.2 → XP_030108308.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q923E3, Q99JU7
      Conserved Domains (2) summary
      pfam12496
      Location:50 → 178
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:180 → 317
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JU7.1 GenPept UniProtKB/Swiss-Prot:Q99JU7

    Gene LinkOut

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