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    Pabpn1 poly(A) binding protein, nuclear 1 [ Mus musculus (house mouse) ]

    Gene ID: 54196, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pabpn1provided by MGI
    Official Full Name
    poly(A) binding protein, nuclear 1provided by MGI
    Primary source
    MGI:MGI:1859158
    See related
    Ensembl:ENSMUSG00000022194 AllianceGenome:MGI:1859158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAB2; Pabp3; mPABII
    Summary
    Enables RNA polymerase binding activity. Involved in MAPK cascade; cellular response to lipopolysaccharide; and positive regulation of polynucleotide adenylyltransferase activity. Located in nucleus. Part of ribonucleoprotein complex. Is expressed in central nervous system; sensory organ; and thymus. Used to study oculopharyngeal muscular dystrophy. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 169.0), CNS E14 (RPKM 167.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pabpn1 in Genome Data Viewer
    Location:
    14 C3; 14 27.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55131600..55136384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54894143..54898927)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene BCL2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E754 Neighboring gene solute carrier family 22 (organic cation transporter), member 17 Neighboring gene embryonal Fyn-associated substrate Neighboring gene STARR-seq mESC enhancer starr_36750 Neighboring gene interleukin 25

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    polyadenylate-binding protein 2
    Names
    PABII
    PABP-2
    nuclear poly(A)-binding protein 1
    poly(A) binding protein II
    poly(A)-binding protein 2
    polyadenylate-binding nuclear protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019402.2NP_062275.1  polyadenylate-binding protein 2

      See identical proteins and their annotated locations for NP_062275.1

      Status: VALIDATED

      Source sequence(s)
      AC116591, AK032172, BY266376
      Consensus CDS
      CCDS27104.1
      UniProtKB/Swiss-Prot
      O35935, Q8CCS6
      UniProtKB/TrEMBL
      G3UY42
      Related
      ENSMUSP00000022808.8, ENSMUST00000022808.14
      Conserved Domains (2) summary
      COG0724
      Location:109285
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:169244
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55131600..55136384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)