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    Ttll9 tubulin tyrosine ligase-like family, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 74711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttll9provided by MGI
    Official Full Name
    tubulin tyrosine ligase-like family, member 9provided by MGI
    Primary source
    MGI:MGI:1913589
    See related
    Ensembl:ENSMUSG00000074673 AllianceGenome:MGI:1913589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700016F23Rik; 4930509O20Rik
    Summary
    Enables tubulin-glutamic acid ligase activity. Acts upstream of or within flagellated sperm motility and protein polyglutamylation. Located in ciliary basal body. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Orthologous to human TTLL9 (tubulin tyrosine ligase like 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 39.3) and genital fat pad adult (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    See Ttll9 in Genome Data Viewer
    Location:
    2 H1; 2 75.41 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152792966..152850402)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152951046..153008482)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10154 Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle Neighboring gene forkhead box S1 Neighboring gene STARR-seq mESC enhancer starr_06085 Neighboring gene dual specificity phosphatase-like 15 Neighboring gene STARR-seq mESC enhancer starr_06086 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene p53 and DNA damage regulated 1 Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating. Konno A, et al. J Cell Sci, 2016 Jul 15. PMID 27257088
    2. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    3. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns.
      Title: Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamic acid ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein polyglutamylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable tubulin polyglutamylase TTLL9
    Names
    putative polyglutamylase
    tubulin tyrosine ligase like family 9
    tubulin--tyrosine ligase-like protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083618.1 → NP_001077087.1  probable tubulin polyglutamylase TTLL9 isoform 1

      See identical proteins and their annotated locations for NP_001077087.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AK006027, AK015388, AK041200
      Consensus CDS
      CCDS38283.1
      UniProtKB/Swiss-Prot
      A2APC3, A2APC4, A2APC5, A2APC6, Q9D570
      Related
      ENSMUSP00000096803.3, ENSMUST00000099197.9
      Conserved Domains (1) summary
      pfam03133
      Location:74 → 390
      TTL; Tubulin-tyrosine ligase family

    2. NM_001355717.1 → NP_001342646.1  probable tubulin polyglutamylase TTLL9 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate coding exons compared to variant 2. The resulting isoform (3) differs in the N-terminus and lacks an alternate internal segment compared to isoform 2.
      Source sequence(s)
      AL833801, AL928862
      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      cl17255
      Location:31 → 328
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    3. NM_001355719.1 → NP_001342648.1  probable tubulin polyglutamylase TTLL9 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 2.
      Source sequence(s)
      AL833801, AL928862
      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      cl17255
      Location:31 → 328
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    4. NM_001355720.1 → NP_001342649.1  probable tubulin polyglutamylase TTLL9 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AL833801, AL928862
      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:1 → 296
      TTL; Tubulin-tyrosine ligase family

    5. NM_029064.2 → NP_083340.2  probable tubulin polyglutamylase TTLL9 isoform 2

      See identical proteins and their annotated locations for NP_083340.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AK006027, AK015740, AL833801
      Consensus CDS
      CCDS16903.1
      UniProtKB/TrEMBL
      A7E1Z2
      Related
      ENSMUSP00000099444.4, ENSMUST00000103155.10
      Conserved Domains (1) summary
      pfam03133
      Location:74 → 390
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152792966..152850402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252160.1 → XP_030108020.1  probable tubulin polyglutamylase TTLL9 isoform X6

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:1 → 296
      TTL; Tubulin-tyrosine ligase family

    2. XM_030252156.2 → XP_030108016.1  probable tubulin polyglutamylase TTLL9 isoform X4

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family

    3. XM_030252153.2 → XP_030108013.1  probable tubulin polyglutamylase TTLL9 isoform X2

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:63 → 379
      TTL; Tubulin-tyrosine ligase family

    4. XM_030252155.2 → XP_030108015.1  probable tubulin polyglutamylase TTLL9 isoform X4

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family

    5. XM_030252161.2 → XP_030108021.1  probable tubulin polyglutamylase TTLL9 isoform X8

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      cl17255
      Location:58 → 296
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    6. XM_030252158.1 → XP_030108018.1  probable tubulin polyglutamylase TTLL9 isoform X5

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family

    7. XM_030252157.2 → XP_030108017.1  probable tubulin polyglutamylase TTLL9 isoform X4

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family

    8. XM_030252152.1 → XP_030108012.1  probable tubulin polyglutamylase TTLL9 isoform X1

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:74 → 390
      TTL; Tubulin-tyrosine ligase family

    9. XM_006500320.2 → XP_006500383.1  probable tubulin polyglutamylase TTLL9 isoform X7

      Conserved Domains (1) summary
      pfam03133
      Location:1 → 296
      TTL; Tubulin-tyrosine ligase family

    10. XM_030252154.1 → XP_030108014.1  probable tubulin polyglutamylase TTLL9 isoform X3

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:63 → 379
      TTL; Tubulin-tyrosine ligase family

    11. XM_030252159.1 → XP_030108019.1  probable tubulin polyglutamylase TTLL9 isoform X5

      UniProtKB/TrEMBL
      A7E1Z2
      Conserved Domains (1) summary
      pfam03133
      Location:42 → 358
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2APC3.2 GenPept UniProtKB/Swiss-Prot:A2APC3

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