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    Eme2 essential meiotic structure-specific endonuclease subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 193838, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eme2provided by MGI
    Official Full Name
    essential meiotic structure-specific endonuclease subunit 2provided by MGI
    Primary source
    MGI:MGI:1919889
    See related
    Ensembl:ENSMUSG00000073436 AllianceGenome:MGI:1919889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810013J18Rik
    Summary
    Predicted to enable DNA binding activity and endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. Predicted to be part of Holliday junction resolvase complex. Is expressed in medial ganglionic eminence. Orthologous to human EME2 (essential meiotic structure-specific endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.5), genital fat pad adult (RPKM 15.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eme2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25111126..25114061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24892152..24895087, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene STARR-positive B cell enhancer ABC_E216 Neighboring gene nucleotide binding protein 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene mitogen-activated protein kinase 8 interacting protein 3 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Holliday junction resolvase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of endodeoxyribonuclease complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear replication fork NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    probable crossover junction endonuclease EME2
    Names
    essential meiotic endonuclease 1 homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163102.1NP_001156574.1  probable crossover junction endonuclease EME2

      See identical proteins and their annotated locations for NP_001156574.1

      Status: VALIDATED

      Source sequence(s)
      BC092228, BY148623
      Consensus CDS
      CCDS50023.1
      UniProtKB/Swiss-Prot
      Q56A04
      UniProtKB/TrEMBL
      D3Z6X0
      Related
      ENSMUSP00000113936.2, ENSMUST00000121542.2
      Conserved Domains (1) summary
      pfam02732
      Location:74244
      ERCC4; ERCC4 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25111126..25114061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)