Upk3b uroplakin 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Upk3bprovided by MGI
Official Full Name: uroplakin 3Bprovided by MGI
Primary source: MGI:MGI:2140882
See related: Ensembl:ENSMUSG00000042985 AllianceGenome:MGI:2140882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P35; UpIIIb; PMS2L14
Summary: Involved in negative regulation of D-glucose import. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in heart; intraembryonic coelom; proepicardium; and urinary system. Orthologous to human UPK3B (uroplakin 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 78.2), lung adult (RPKM 49.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.7 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136067350..136073847)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136038496..136044993)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that UPK3B may play a pivotal role in the maturation of gametes and gamete-delivery organs.
Title: Spatiotemporal expression of UPK3B and its promoter activity during embryogenesis and spermatogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491848

AI957187 (e-PCR)
- UniSTS:179290

Upk3b (e-PCR), detects polymorphism
- UniSTS:527020

AI447729 (e-PCR)
- UniSTS:159461

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uroplakin-3b

Names: UP3b; uroplakin IIIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.