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    Drc1 dynein regulatory complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 381738, updated on 9-Dec-2024

    Summary

    Official Symbol
    Drc1provided by MGI
    Official Full Name
    dynein regulatory complex subunit 1provided by MGI
    Primary source
    MGI:MGI:2685906
    See related
    Ensembl:ENSMUSG00000073102 AllianceGenome:MGI:2685906
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1060; Ccdc164; b2b1654Clo
    Summary
    Acts upstream of or within several processes, including cilium assembly; determination of left/right symmetry; and single fertilization. Is active in cytosol and sperm flagellum. Is expressed in several structures, including brain; nasal cavity respiratory epithelium; and respiratory system epithelium. Used to study Kartagener syndrome; primary ciliary dyskinesia 21; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 21 and spermatogenic failure 80. Orthologous to human DRC1 (dynein regulatory complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 10.4), cortex adult (RPKM 2.7) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Drc1 in Genome Data Viewer
    Location:
    5 B1; 5 16.42 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30486328..30524039)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30281335..30366695)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1678 Neighboring gene predicted gene, 54326 Neighboring gene selenoprotein I Neighboring gene predicted gene 16288 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30645501-30645684 Neighboring gene otoferlin Neighboring gene STARR-seq mESC enhancer starr_12752 Neighboring gene ciliary microtubule inner protein 2C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axonemal dynein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cilium-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium-dependent cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sperm flagellum assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in sperm flagellum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    dynein regulatory complex protein 1
    Names
    coiled-coil domain containing 164
    coiled-coil domain-containing protein 164

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033460.4NP_001028632.1  dynein regulatory complex protein 1

      See identical proteins and their annotated locations for NP_001028632.1

      Status: VALIDATED

      Source sequence(s)
      AC241618, AC242405
      Consensus CDS
      CCDS84857.1
      UniProtKB/Swiss-Prot
      B9EKF0, Q3USS3
      Related
      ENSMUSP00000098992.4, ENSMUST00000101448.5
      Conserved Domains (2) summary
      pfam14772
      Location:100200
      NYD-SP28; Sperm tail
      pfam14775
      Location:673731
      NYD-SP28_assoc; Sperm tail C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30486328..30524039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320953.3XP_017176442.1  dynein regulatory complex protein 1 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:117372
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam14772
      Location:100200
      NYD-SP28; Sperm tail
      pfam14775
      Location:644699
      NYD-SP28_assoc; Sperm tail C-terminal domain
    2. XM_017320954.2XP_017176443.1  dynein regulatory complex protein 1 isoform X3

      Conserved Domains (1) summary
      pfam14775
      Location:467526
      NYD-SP28_assoc; Sperm tail C-terminal domain
    3. XM_036165255.1XP_036021148.1  dynein regulatory complex protein 1 isoform X3

      Conserved Domains (1) summary
      pfam14775
      Location:467526
      NYD-SP28_assoc; Sperm tail C-terminal domain
    4. XM_030254633.1XP_030110493.1  dynein regulatory complex protein 1 isoform X4

      Conserved Domains (2) summary
      pfam09787
      Location:3149
      Golgin_A5; Golgin subfamily A member 5
      pfam14775
      Location:438493
      NYD-SP28_assoc; Sperm tail C-terminal domain
    5. XM_036165253.1XP_036021146.1  dynein regulatory complex protein 1 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:13246
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam14772
      Location:145
      NYD-SP28; Sperm tail
      pfam14775
      Location:518577
      NYD-SP28_assoc; Sperm tail C-terminal domain
    6. XM_036165254.1XP_036021147.1  dynein regulatory complex protein 1 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:13246
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam14772
      Location:145
      NYD-SP28; Sperm tail
      pfam14775
      Location:518577
      NYD-SP28_assoc; Sperm tail C-terminal domain