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    SLM5 asparagine--tRNA ligase SLM5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850388, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SLM5
    Official Full Name
    asparagine--tRNA ligase SLM5
    Primary source
    SGD:S000000618
    Locus tag
    YCR024C
    See related
    AllianceGenome:SGD:S000000618; FungiDB:YCR024C; VEuPathDB:YCR024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables asparagine-tRNA ligase activity. Involved in mitochondrial asparaginyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SLM5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (160744..162222, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene proteolipid ATPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial asparaginyl-tRNA synthetase is encoded by the yeast nuclear gene YCR24c. Landrieu I, et al. Eur J Biochem, 1997 Jan 15. PMID 9030748
    2. The complete sequence of K3B, a 7.9 kb fragment between PGK1 and CRY1 on chromosome III, reveals the presence of seven open reading frames. Bolle PA, et al. Yeast, 1992 Mar. PMID 1574926
    3. The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length. Vernekar DV, et al. Nucleic Acids Res, 2021 May 7. PMID 33823531, Free PMC Article
    4. Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Merz S, et al. Genome Biol, 2009. PMID 19751518, Free PMC Article
    5. Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. Audhya A, et al. EMBO J, 2004 Oct 1. PMID 15372071, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparagine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in asparaginyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial asparaginyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asparagine--tRNA ligase SLM5
    NP_009953.1
    • Mitochondrial asparaginyl-tRNA synthetase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      160744..162222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178738.1 → NP_009953.1  TPA: asparagine--tRNA ligase SLM5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR33, P25345
      UniProtKB/TrEMBL
      A6ZTK5, B3LU95, B5VEX1, C7GW72, G2WA41, N1P840
      Conserved Domains (1) summary
      TIGR00457
      Location:16 → 492
      asnS; asparaginyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25345.1

    Gene LinkOut

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