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    RHB1 putative GTPase RHB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RHB1
    Official Full Name
    putative GTPase RHB1
    Primary source
    SGD:S000000622
    Locus tag
    YCR027C
    See related
    AllianceGenome:SGD:S000000622; FungiDB:YCR027C; VEuPathDB:YCR027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RSG1
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in retrograde transport, endosome to Golgi. Located in cytosol. Orthologous to human RHEBL1 (RHEB like 1) and RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RHB1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (167370..167999, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nucleotide diphosphatase/phosphodiesterase NPP1 Neighboring gene tRNA-Gln Neighboring gene Fen2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Chattopadhyay S, et al. Eukaryot Cell, 2002 Aug. PMID 12456008, Free PMC Article
    2. The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake. Urano J, et al. J Biol Chem, 2000 Apr 14. PMID 10753927
    3. Evolution of the TOR pathway. van Dam TJ, et al. J Mol Evol, 2011 Oct. PMID 22057117, Free PMC Article
    4. Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens. Dengjel J, et al. Mol Cell Proteomics, 2012 Mar. PMID 22311637, Free PMC Article
    5. Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination. Annan RB, et al. Eukaryot Cell, 2008 Sep. PMID 18621925, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative GTPase RHB1
    NP_009956.2
    • Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      167370..167999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178742.1 → NP_009956.2  TPA: putative GTPase RHB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009956.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR37, P25378, Q8NKJ6
      UniProtKB/TrEMBL
      A6ZTK8, B3LU98, B5VEX4, C7GW69, C8Z4B8, G2WA45, N1P6A7
      Conserved Domains (1) summary
      cd04137
      Location:16 → 209
      RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25378.2

    Gene LinkOut

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