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    REC107 Rec107p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    REC107
    Official Full Name
    Rec107p
    Primary source
    SGD:S000003782
    Locus tag
    YJR021C
    See related
    AllianceGenome:SGD:S000003782; FungiDB:YJR021C; VEuPathDB:YJR021C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MER2
    Summary
    Involved in reciprocal meiotic recombination. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REC107 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_001142.9 (468555..469579, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase ESS1 Neighboring gene palmitoyl-CoA hydrolase Neighboring gene U4/U6-U5 snRNP complex subunit LSM8 Neighboring gene methylthioribulose 1-phosphate dehydratase MDE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of the structure and function of meiotic Rec114-Mei4 and Mer2 complexes. Daccache D, et al. Genes Dev, 2023 Jun 1. PMID 37442581, Free PMC Article
    2. The yeast MER2 gene is required for chromosome synapsis and the initiation of meiotic recombination. Rockmill B, et al. Genetics, 1995 Sep. PMID 8536989, Free PMC Article
    3. Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor. Nandabalan K, et al. Cell, 1993 Apr 23. PMID 8477451
    4. Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation. Rousová D, et al. Elife, 2021 Dec 24. PMID 34951404, Free PMC Article
    5. Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Sasanuma H, et al. Genes Dev, 2008 Feb 1. PMID 18245451, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation.
      Title: Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation.
    2. ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
      Title: ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
    3. DNA-driven condensation assembles the meiotic DNA break machinery.
      Title: DNA-driven condensation assembles the meiotic DNA break machinery.
    4. Study provides evidence that a key prerequisite for double-strand breaks formation-phosphorylation of Mer2 by Dbf4-dependent Cdc7 kinase, DDK-is linked to replication via association of the kinase with replisome components.
      Title: Temporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes.
    5. Cdc7, in concert with CDK, regulates Spo11 loading to DSB sites via Mer2 phosphorylation.
      Title: Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.
    6. Mer2, Mei4, and Rec114 form a distinct complex required for double-strand breaks formation.
      Title: Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rec107p
    NP_012555.1
    • Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      468555..469579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181679.1 → NP_012555.1  TPA: Rec107p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWJ5, P21651
      UniProtKB/TrEMBL
      A6ZPY7, G2WH32, N1P3D5
      Conserved Domains (1) summary
      pfam09074
      Location:26 → 214
      Mer2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21651.2

    Gene LinkOut

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