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    IRS4 Irs4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IRS4
    Official Full Name
    Irs4p
    Primary source
    SGD:S000001727
    Locus tag
    YKR019C
    See related
    AllianceGenome:SGD:S000001727; FungiDB:YKR019C; VEuPathDB:YKR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in autophagy; fungal-type cell wall organization; and rDNA heterochromatin formation. Located in phagophore assembly site. Orthologous to several human genes including EHD1 (EH domain containing 1); EHD2 (EH domain containing 2); and EHD3 (EH domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IRS4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (476216..478063, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase HEL1 Neighboring gene uncharacterized protein Neighboring gene Vps51p Neighboring gene Aly1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recognition specificity of individual EH domains of mammals and yeast. Paoluzi S, et al. EMBO J, 1998 Nov 16. PMID 9822599, Free PMC Article
    2. Irs4p and Tax4p: two redundant EH domain proteins involved in autophagy. Bugnicourt A, et al. Traffic, 2008 May. PMID 18298591
    3. Siz2 Prevents Ribosomal DNA Recombination by Modulating Levels of Tof2 in Saccharomyces cerevisiae. Abraham NM, et al. mSphere, 2019 Nov 27. PMID 31776241, Free PMC Article
    4. Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4. Morales-Johansson H, et al. J Biol Chem, 2004 Sep 17. PMID 15265867
    5. Role for perinuclear chromosome tethering in maintenance of genome stability. Mekhail K, et al. Nature, 2008 Dec 4. PMID 18997772, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Irs4p
    NP_012944.3
    • EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      476216..478063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179809.3 → NP_012944.3  TPA: Irs4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012944.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZY3, D6VX84, P36115
      UniProtKB/TrEMBL
      G2WI50, N1NZF9
      Conserved Domains (1) summary
      cl27812
      Location:498 → 570
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36115.1

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