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    REH1 Reh1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    REH1
    Official Full Name
    Reh1p
    Primary source
    SGD:S000004379
    Locus tag
    YLR387C
    See related
    AllianceGenome:SGD:S000004379; FungiDB:YLR387C; VEuPathDB:YLR387C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable zinc ion binding activity. Involved in ribosomal large subunit biogenesis. Located in cytoplasm. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REH1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (896374..897672, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Swc7p Neighboring gene Vac14p Neighboring gene ribosomal 40S subunit protein S29A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ybr267w is a new cytoplasmic protein belonging to the mitotic signaling network of Saccharomyces cerevisiae. Iwase M, et al. Cell Struct Funct, 2004 Feb. PMID 15107529
    2. Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S subunit maturation. Parnell KM, et al. Mol Cell Biol, 2009 Jul. PMID 19433447, Free PMC Article
    3. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. Lebreton A, et al. J Cell Biol, 2006 May 8. PMID 16651379, Free PMC Article
    4. Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1. Ma C, et al. Nat Struct Mol Biol, 2017 Mar. PMID 28112732, Free PMC Article
    5. Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation. Greber BJ, et al. Cell, 2016 Jan 14. PMID 26709046

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Reh1p
    NP_013491.1
    • Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      896374..897672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182276.1 → NP_013491.1  TPA: Reh1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013491.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ22, Q06709, Q7LIF0
      UniProtKB/TrEMBL
      A7A1R2, B3RHQ2, C7GXJ1, C8ZDZ6, G2WJK2, N1P051
      Conserved Domains (3) summary
      PTZ00448
      Location:1 → 54
      PTZ00448; hypothetical protein; Provisional
      sd00020
      Location:8 → 30
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12756
      Location:188 → 285
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06709.1

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