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    REXO1L1P REXO1 like 1, pseudogene [ Homo sapiens (human) ]

    Gene ID: 254958, updated on 27-Dec-2024

    Summary

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    Official Symbol
    REXO1L1Pprovided by HGNC
    Official Full Name
    REXO1 like 1, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:24660
    See related
    AllianceGenome:HGNC:24660
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GOR; REXO1L1
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REXO1L1P in Genome Data Viewer
    Location:
    8q21.2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (85661256..85662410, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (86204232..86205386, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86573485..86574639, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene REXO1 like 8, pseudogene Neighboring gene OCT4 hESC enhancer GRCh37_chr8:86560715-86561216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:86567267-86568134 Neighboring gene REXO1 like 3, pseudogene Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:86573707-86574476 Neighboring gene REXO1 like 12, pseudogene Neighboring gene putative exonuclease GOR Neighboring gene REXO1 like 11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serum immunoglobulin G antibodies to the GOR autoepitope are present in patients with occult hepatitis C virus (HCV) infection despite lack of HCV-specific antibodies. Quiroga JA, et al. Clin Vaccine Immunol, 2007 Oct. PMID 17699833, Free PMC Article
    2. The GOR gene product cannot cross-react with hepatitis C virus in humans. Koike R, et al. Clin Exp Immunol, 2001 Jun. PMID 11472404, Free PMC Article
    3. The GOR47-1 sequence in human DNA encoding for a potential autoantigen in connection with hepatitis C--a sequence not only reserved for humans. Dennin RH, et al. Z Gastroenterol, 1998 Oct. PMID 9846365
    4. Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Mishiro S, et al. Lancet, 1990 Dec 8. PMID 1701012
    5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sera from 20% of patients with occult hepatitis C infection react with the GOR autoepitope in enzyme immumoassays, although this frequency is lower than the GOR reactivity of patients with chronic hepatitis C.
      Title: Serum immunoglobulin G antibodies to the GOR autoepitope are present in patients with occult hepatitis C virus (HCV) infection despite lack of HCV-specific antibodies.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • REX1, RNA exonuclease 1 homolog-like 1, pseudogene
    • antigen GOR homolog
    • exonuclease GOR

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053157.1 

      Range
      101..1255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      85661256..85662410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      86204232..86205386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172239.4: Suppressed sequence

      Description
      NM_172239.4: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX06.2 GenPept UniProtKB/Swiss-Prot:Q8IX06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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