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    VEGFC vascular endothelial growth factor C [ Homo sapiens (human) ]

    Gene ID: 7424, updated on 4-Jan-2025

    Summary

    Official Symbol
    VEGFCprovided by HGNC
    Official Full Name
    vascular endothelial growth factor Cprovided by HGNC
    Primary source
    HGNC:HGNC:12682
    See related
    Ensembl:ENSG00000150630 MIM:601528; AllianceGenome:HGNC:12682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VRP; Flt4-L; LMPH1D; LMPHM4
    Summary
    The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
    Expression
    Broad expression in thyroid (RPKM 17.4), placenta (RPKM 7.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See VEGFC in Genome Data Viewer
    Location:
    4q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (176683538..176792922, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (180022579..180131932, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (177604689..177714076, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900817 Neighboring gene cutaneous T cell lymphoma-associated antigen 1 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:177613493-177614380 Neighboring gene HuR (ELAVL1) associated fibroblast migratory lncRNA Neighboring gene long intergenic non-protein coding RNA 2509 Neighboring gene RN7SK pseudogene 136

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (14 hits/1262 screens)

    Associated conditions

    Description Tests
    Lymphatic malformation 4
    MedGen: C4747769 OMIM: 615907 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed
    tat HIV-1 Tat enhances vIL-6-induced angiogenesis and tumorigenesis of fibroblasts and human endothelial cells, which correlates with upregulation of CD31, CD34, SMA, VEGF, b-FGF, and cyclin D1 expression PubMed
    tat HIV-1 Tat enhances Kaposi's sarcoma-associated herpesvirus vIL-6-induced cell proliferation, cellular transformation, vascular tube formation, and VEGF production in tumor cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables chemoattractant activity PubMed 
    enables growth factor activity  
    enables protein binding PubMed 
    enables vascular endothelial growth factor receptor 3 binding  
    enables vascular endothelial growth factor receptor 3 binding PubMed 
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis  
    involved_in cellular response to leukemia inhibitory factor  
    involved_in glial cell proliferation  
    involved_in induction of positive chemotaxis  
    involved_in induction of positive chemotaxis PubMed 
    involved_in morphogenesis of embryonic epithelium  
    involved_in negative regulation of blood pressure  
    involved_in negative regulation of osteoblast differentiation  
    involved_in positive chemotaxis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of lymphangiogenesis  
    involved_in positive regulation of mast cell chemotaxis  
    involved_in positive regulation of mast cell chemotaxis PubMed 
    involved_in positive regulation of mesenchymal stem cell proliferation  
    involved_in positive regulation of neuroblast proliferation  
    involved_in positive regulation of protein secretion  
    involved_in regulation of vascular endothelial growth factor receptor signaling pathway  
    involved_in response to hypoxia  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction PubMed 
    involved_in sprouting angiogenesis  
    involved_in substrate-dependent cell migration PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor receptor signaling pathway PubMed 
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in extracellular region  
    is_active_in extracellular space  
    located_in membrane  
    located_in platelet alpha granule lumen  

    General protein information

    Preferred Names
    vascular endothelial growth factor C
    Names
    FLT4 ligand DHM
    vascular endothelial growth factor-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034216.1 RefSeqGene

      Range
      4824..114208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005429.5 → NP_005420.1  vascular endothelial growth factor C preproprotein

      See identical proteins and their annotated locations for NP_005420.1

      Status: REVIEWED

      Source sequence(s)
      AC092673, AW294939, BC063685, DA044965
      Consensus CDS
      CCDS43285.1
      UniProtKB/Swiss-Prot
      B2R9Q8, P49767
      UniProtKB/TrEMBL
      Q6FH59
      Related
      ENSP00000480043.1, ENST00000618562.2
      Conserved Domains (1) summary
      smart00141
      Location:129 → 213
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      176683538..176792922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      180022579..180131932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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