Apold1 apolipoprotein L domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apold1provided by MGI
Official Full Name: apolipoprotein L domain containing 1provided by MGI
Primary source: MGI:MGI:2685921
See related: Ensembl:ENSMUSG00000090698 AllianceGenome:MGI:2685921
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1075
Summary: Predicted to enable lipid binding activity. Predicted to be involved in angiogenesis and regulation of endothelial cell differentiation. Is expressed in heart ventricle. Orthologous to human APOLD1 (apolipoprotein L domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 3.7), ovary adult (RPKM 1.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.77 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (134958964..134963799)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (134982001..134986836)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions.
Title: The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions.
Apold1 deficiency associates with increased arterial thrombosis in vivo.
Title: Apold1 deficiency associates with increased arterial thrombosis in vivo.
The resiults of this study suggests that Verge plays an important role in the induction of neurogenesis and angiogenesis after ischemia, contributes to improved tissue repair, and enhances chronic functional recovery.
Title: Knockout of vascular early response gene worsens chronic stroke outcomes in neonatal mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endothelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: apolipoprotein L domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109914.1 → NP_001103384.1 apolipoprotein L domain-containing protein 1

Status: PROVISIONAL

Source sequence(s)

AC122193

Consensus CDS

CCDS51938.1

UniProtKB/TrEMBL

E9Q0X2

Related

ENSMUSP00000132366.2, ENSMUST00000167323.3

Conserved Domains (1) summary

pfam05461
Location:69 → 105

ApoL; Apolipoprotein L