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    thoc7 thoc7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    thoc7provided by FlyBase
    Official Full Name
    thoc7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035110
    Locus tag
    Dmel_CG17143
    See related
    AllianceGenome:FB:FBgn0035110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17143; Dmel\CG17143; Thoc7; THOC7
    Summary
    Predicted to be involved in mRNA export from nucleus. Located in nucleus. Part of THO complex. Is expressed in adult head; egg chamber; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human THOC7 (THO complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See thoc7 in Genome Data Viewer
    Location:
    61B2-61B2; 3-1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (211636..212687, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (211636..212687, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein Neighboring gene uncharacterized protein Neighboring gene Pre-mRNA processing factor 4 kinase Neighboring gene Dis3 like 3'-5' exoribonuclease 2 Neighboring gene pseudo Neighboring gene Kaz1-ORFB

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
    2. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
    3. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
    4. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Kopytova DV, et al. Genes Dev, 2010 Jan 1. PMID 20048002, Free PMC Article
    5. Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila. Hur JK, et al. Genes Dev, 2016 Apr 1. PMID 27036967, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus in response to heat stress IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription export complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    thoc7
    Names
    CG17143-PA
    CG17143-PB
    thoc7-PA
    thoc7-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      211636..212687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138167.1 → NP_612011.1  thoc7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRJ8
      Related
      FBpp0072426, FBtr0072527
      Conserved Domains (1) summary
      pfam05615
      Location:23 → 151
      THOC7; Tho complex subunit 7

    2. NM_167804.2 → NP_728489.2  thoc7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728489.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1WWD6, Q8IRJ8, Q9W0T8
      Conserved Domains (1) summary
      pfam05615
      Location:24 → 152
      THOC7; Tho complex subunit 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRJ8.2 Q8IRJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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