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    ADD1 ADD domain-containing protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36278, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ADD1provided by FlyBase
    Official Full Name
    ADD domain-containing protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0026573
    Locus tag
    Dmel_CG8290
    See related
    AllianceGenome:FB:FBgn0026573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD29214; CG8290; dadd1; dAdd1; dADD1; Dmel\CG8290; LD29214
    Summary
    Enables chromatin DNA binding activity and methylated histone binding activity. Involved in regulatory ncRNA-mediated heterochromatin formation. Located in pericentric heterochromatin and polytene chromosome. Is expressed in several structures, including antennal anlage; central brain anlage; central brain primordium; dorsal head epidermis anlage; and ganglia. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ADD1 in Genome Data Viewer
    Location:
    48D5-48D5; 2-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11970686..11977721)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7858191..7865226)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44312 Neighboring gene expansion Neighboring gene Proteasome inhibitor 31 kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene beta1,3-galactosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. López-Falcón B, et al. PLoS One, 2014. PMID 25437195, Free PMC Article
    2. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres. Chavez J, et al. Chromosoma, 2017 Dec. PMID 28688038
    3. Interplay of pericentromeric genome organization and chromatin landscape regulates the expression of Drosophila melanogaster heterochromatic genes. Saha P, et al. Epigenetics Chromatin, 2020 Oct 7. PMID 33028366, Free PMC Article
    4. Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster. Park SY, et al. Genes Dis, 2023 Nov. PMID 37554213, Free PMC Article
    5. The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size. Iordanou E, et al. Dev Biol, 2014 Sep 1. PMID 24973580, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple Roles of dXNP and dADD1-Drosophila Orthologs of ATRX Chromatin Remodeler.
      Title: Multiple Roles of dXNP and dADD1-Drosophila Orthologs of ATRX Chromatin Remodeler.
    2. dadd1-encoded proteins participate with dAtrx in some cellular functions such as heterochromatin maintenance
      Title: Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADD domain-containing protein 1
    Names
    ADD1-PA
    ADD1-PB
    ADD1-PE
    CG8290-PA
    CG8290-PB
    CG8290-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11970686..11977721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165856.2 → NP_725094.1  ADD domain-containing protein 1, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8R2, Q86PD1
      Related
      FBpp0087148
      Conserved Domains (1) summary
      cd11726
      Location:62 → 164
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)

    2. NM_136872.3 → NP_610716.1  ADD domain-containing protein 1, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961B8
      Related
      FBpp0087147
      Conserved Domains (3) summary
      smart00595
      Location:758 → 840
      MADF; subfamily of SANT domain
      cd11726
      Location:62 → 164
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam10545
      Location:1034 → 1123
      MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like

    3. NM_001299394.1 → NP_001286323.1  ADD domain-containing protein 1, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEU5
      Conserved Domains (3) summary
      smart00595
      Location:612 → 694
      MADF; subfamily of SANT domain
      cd11726
      Location:62 → 164
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam10545
      Location:888 → 977
      MADF_DNA_bdg; Alcohol dehydrogenase transcription factor Myb/SANT-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEU5 A0A0B4LEU5
    A1Z8R2 A1Z8R2
    Q86PD1 Q86PD1
    Q960S5 Q960S5
    Q961B8 Q961B8

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