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    Pp2B-14D Protein phosphatase 2B at 14D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pp2B-14Dprovided by FlyBase
    Official Full Name
    Protein phosphatase 2B at 14Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011826
    Locus tag
    Dmel_CG9842
    See related
    AllianceGenome:FB:FBgn0011826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    calneur; CaN; canA; CanA; CaNA; CanA14D; CG9842; CnA; CnnA14D; D33; Dmel\CG9842; DmPp2B-14D; Pp12-14D; Pp2B; PP2B; PP2B 14D; Pp2b-14D; PP2B-14D; Pp2B-14D/CaN; Pp2B-14DF; PpD33
    Summary
    Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including female meiotic nuclear division; regulation of embryonic development; and sleep. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult head; central nervous system; organism; and presumptive embryonic/larval peripheral nervous system. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pp2B-14D in Genome Data Viewer
    Location:
    14E1-14E3; 1-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16554627..16560016, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16448660..16454049, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2 Neighboring gene Calcineurin A at 14F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo. Brown L, et al. FEBS Lett, 1994 Feb 14. PMID 8313960
    2. Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila. Zarndt R, et al. Circ Cardiovasc Genet, 2017 Oct. PMID 28986453, Free PMC Article
    3. Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Takeo S, et al. Dev Biol, 2010 Aug 15. PMID 20561515
    4. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Schulz RA, et al. Dev Biol, 2004 Feb 1. PMID 14729474
    5. The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy. Dondi C, et al. Cell Rep, 2024 Aug 27. PMID 39093699, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcineurin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 2B at 14D
    Names
    CG9842-PA
    CG9842-PB
    CG9842-PC
    Pp2B-14D-PA
    Pp2B-14D-PB
    Pp2B-14D-PC
    calcineurin
    protein phosphatase D33
    protein phosphatase from PCR fragment D33
    NP_001245715.1
    NP_001245716.1
    NP_523373.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16554627..16560016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258786.3 → NP_001245715.1  protein phosphatase 2B at 14D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q26248, Q27889, Q9VXF2
      UniProtKB/TrEMBL
      M9NE01
      Conserved Domains (1) summary
      cd07416
      Location:107 → 411
      MPP_PP2B; PP2B, metallophosphatase domain

    2. NM_001258787.2 → NP_001245716.1  protein phosphatase 2B at 14D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245716.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q26248, Q27889, Q9VXF2
      UniProtKB/TrEMBL
      M9NE01
      Conserved Domains (1) summary
      cd07416
      Location:107 → 411
      MPP_PP2B; PP2B, metallophosphatase domain

    3. NM_078649.4 → NP_523373.2  protein phosphatase 2B at 14D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523373.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q26248, Q27889, Q9VXF2
      UniProtKB/TrEMBL
      M9NE01
      Related
      FBpp0074069
      Conserved Domains (1) summary
      cd07416
      Location:107 → 411
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NE01 M9NE01
    Q27889.2 Q27889
    Q7JPT8 Q7JPT8

    Gene LinkOut

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