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    CG8907 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8907provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038466
    Locus tag
    Dmel_CG8907
    See related
    AllianceGenome:FB:FBgn0038466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8907; LP01469p
    Summary
    Predicted to be involved in olfactory behavior. Predicted to be located in synapse. Is expressed in adult head; embryonic proventriculus; embryonic/larval midgut; foregut primordium; and proventriculus primordium. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to several human genes including EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8907 in Genome Data Viewer
    Location:
    89E8-89E8; 3-59 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17008269..17012533)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12833991..12838255)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3a subunit 1 Neighboring gene Immune-regulated catalase Neighboring gene Peroxidase Neighboring gene Adenylosuccinate lyase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure. Tocchetti A, et al. Genomics, 2003 Feb. PMID 12620401
    2. Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes. Chatterjee D, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25472843, Free PMC Article
    3. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8907-PA
    CG8907-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17008269..17012533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142328.4 → NP_650585.1  uncharacterized protein Dmel_CG8907, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM2, Q95TJ6, Q9VEP7
      Related
      FBpp0082815
      Conserved Domains (3) summary
      cd11764
      Location:419 → 472
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:23 → 155
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:615 → 679
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001260217.2 → NP_001247146.1  uncharacterized protein Dmel_CG8907, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMM2, H9ZYQ1
      Conserved Domains (3) summary
      cd11764
      Location:439 → 492
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:43 → 175
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
      cl15755
      Location:635 → 699
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9ZYQ1 H9ZYQ1
    Q95TJ6 Q95TJ6

    Gene LinkOut

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