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    CG10738 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10738provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036368
    Locus tag
    Dmel_CG10738
    See related
    AllianceGenome:FB:FBgn0036368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10738; GYC
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in several processes, including Golgi organization; negative regulation of cell size; and positive regulation of mitotic cell cycle. Predicted to be active in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10738 in Genome Data Viewer
    Location:
    70B1-70B1; 3-40 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13450770..13465539)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13443870..13458639)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene combover Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene starvin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. Biswas KH, et al. J Mol Evol, 2009 Jun. PMID 19495554
    2. IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia. Werner S, et al. Life Sci Alliance, 2024 May. PMID 38373798, Free PMC Article
    3. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
    4. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. Zacharogianni M, et al. EMBO J, 2011 Aug 16. PMID 21847093, Free PMC Article
    5. In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer. He L, et al. Elife, 2019 May 29. PMID 31140975, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10738-PC
    CG10738-PD
    CG10738-PE
    CG10738-PF
    NP_001246742.1
    NP_001246743.1
    NP_648653.2
    NP_729905.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13450770..13465539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168547.2 → NP_729905.2  uncharacterized protein Dmel_CG10738, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729905.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU79
      Conserved Domains (7) summary
      cd06370
      Location:41 → 441
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00219
      Location:597 → 847
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:886 → 1078
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:570 → 853
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:913 → 1099
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:67 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:862 → 907
      HNOBA; Heme NO binding associated

    2. NM_001259813.1 → NP_001246742.1  uncharacterized protein Dmel_CG10738, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAF5
      Conserved Domains (7) summary
      cd06370
      Location:41 → 441
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00219
      Location:584 → 834
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:873 → 1065
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:557 → 840
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:900 → 1086
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:67 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:849 → 894
      HNOBA; Heme NO binding associated

    3. NM_140396.2 → NP_648653.2  uncharacterized protein Dmel_CG10738, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648653.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQK2
      Conserved Domains (7) summary
      cd06370
      Location:41 → 441
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00219
      Location:595 → 845
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:884 → 1076
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:568 → 851
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:911 → 1097
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:67 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:860 → 905
      HNOBA; Heme NO binding associated

    4. NM_001259814.1 → NP_001246743.1  uncharacterized protein Dmel_CG10738, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFA6
      Conserved Domains (7) summary
      cd06370
      Location:41 → 441
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00219
      Location:582 → 832
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:871 → 1063
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:555 → 838
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:898 → 1084
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:67 → 416
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:847 → 892
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C7LAF5 C7LAF5
    M9NFA6 M9NFA6
    Q8IQK2 Q8IQK2
    Q9VU79 Q9VU79

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