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    CG2964 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2964provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031462
    Locus tag
    Dmel_CG2964
    See related
    AllianceGenome:FB:FBgn0031462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2964
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Orthologous to human PKM (pyruvate kinase M1/2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2964 in Genome Data Viewer
    Location:
    23B2-23B2; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2812437..2814429)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2812437..2814429)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Synaptotagmin 1 Neighboring gene long non-coding RNA:CR43821 Neighboring gene dawdle Neighboring gene Glucose-6-Phosphatase Neighboring gene Dual oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
    2. Efficient identification of Y chromosome sequences in the human and Drosophila genomes. Carvalho AB, et al. Genome Res, 2013 Nov. PMID 23921660, Free PMC Article
    3. Potential involvement of Drosophila flightless-1 in carbohydrate metabolism. Park JE, et al. BMB Rep, 2018 Sep. PMID 30060781, Free PMC Article
    4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    5. SOD1 activity threshold and TOR signalling modulate VAP(P58S) aggregation via reactive oxygen species-induced proteasomal degradation in a Drosophila model of amyotrophic lateral sclerosis. Chaplot K, et al. Dis Model Mech, 2019 Feb 7. PMID 30635270, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2964-PA
    NP_608713.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2812437..2814429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134869.3 → NP_608713.2  uncharacterized protein Dmel_CG2964 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608713.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T434, Q9VQH0
      Related
      FBpp0077406
      Conserved Domains (2) summary
      TIGR01064
      Location:32 → 512
      pyruv_kin; pyruvate kinase
      cl23794
      Location:32 → 515
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T434 Q8T434
    Q9VQH0 Q9VQH0

    Gene LinkOut

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