slx1 nuclease slx1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: slx1provided by FlyBase
Official Full Name: nuclease slx1provided by FlyBase
Primary source: FLYBASE:FBgn0037263
Locus tag: Dmel_CG18271
See related: AllianceGenome:FB:FBgn0037263
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18271; Dmel\CG18271; Slx1; SLX1
Summary: Predicted to enable 5'-flap endonuclease activity and crossover junction DNA endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination. Part of Slx1-Slx4 complex. Orthologous to human SLX1A (SLX1 homolog A, structure-specific endonuclease subunit) and SLX1B (SLX1 homolog B, structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4641963..4644636)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (467685..470358)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1.
Title: Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 5'-flap endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-flap endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables crossover junction DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Slx1-Slx4 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Slx1-Slx4 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Slx1-Slx4 complex	IEA Inferred from Electronic Annotation more info
part_of Slx1-Slx4 complex	ISS Inferred from Sequence or Structural Similarity more info

NP_649484.3

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The following sections contain reference sequences that belong to a specific genome build. Explain