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    Yip1d1 Yip1 domain-containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yip1d1provided by FlyBase
    Official Full Name
    Yip1 domain-containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032465
    Locus tag
    Dmel_CG12404
    See related
    AllianceGenome:FB:FBgn0032465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12404; Dmel\CG12404; Yip1
    Summary
    Involved in positive regulation of synapse pruning and spermatogenesis. Located in cis-Golgi network and endoplasmic reticulum exit site. Is expressed in adult head. Used to study azoospermia. Orthologous to several human genes including YIPF7 (Yip1 domain family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Yip1d1 in Genome Data Viewer
    Location:
    34A4-34A4; 2-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12993757..13000635, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12993757..13000635, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 68 kDa subunit 2 Neighboring gene Vacuolar H[+] ATPase 68kD subunit 3 Neighboring gene Vacuolar H[+] ATPase 68kD subunit 1 Neighboring gene mechanistic Target of rapamycin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yif1 associates with Yip1 on Golgi and regulates dendrite pruning in sensory neurons during Drosophila metamorphosis. Wang Q, et al. Development, 2018 Jun 13. PMID 29769219
    2. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. Pathak RU, et al. BMC Genomics, 2014 Nov 25. PMID 25424749, Free PMC Article
    3. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Yu J, et al. Hum Mol Genet, 2015 Mar 1. PMID 25361961
    4. Spatiotemporal regulation of developmental neurite pruning: Molecular and cellular insights from Drosophila models. Furusawa K, et al. Neurosci Res, 2021 Jun. PMID 33309868
    5. Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases. Marcogliese PC, et al. Cell Rep, 2022 Mar 15. PMID 35294868, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Yip1 domain-containing 1
    Names
    CG12404-PA
    Yip1d1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12993757..13000635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135752.3 → NP_609596.1  Yip1 domain-containing 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK46
      Related
      FBpp0080011
      Conserved Domains (1) summary
      cl21557
      Location:95 → 264
      Yip1; Yip1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK46 Q9VK46

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