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    Alg-2 Apoptosis-linked gene-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg-2provided by FlyBase
    Official Full Name
    Apoptosis-linked gene-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0086378
    Locus tag
    Dmel_CG40410
    See related
    AllianceGenome:FB:FBgn0086378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ALG-2; CG17661; CG40410; DALG-2; Dmel\CG40410
    Summary
    Predicted to enable calcium ion binding activity. Involved in positive regulation of JNK cascade. Is expressed in organism. Orthologous to human PDCD6 (programmed cell death 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg-2 in Genome Data Viewer
    Location:
    81F5-81F5; 3-47.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3623143..3627690)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1894569..1899116, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene spookier Neighboring gene Poly-(ADP-ribose) polymerase 1 Neighboring gene long non-coding RNA:CR46141 Neighboring gene Translocase of the inner mitochondrial membrane 17b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. Tsuda M, et al. FEBS Lett, 2006 May 29. PMID 16698022
    2. A novel regulator of ER Ca(2+) drives Hippo-mediated tumorigenesis. Ma X, et al. Oncogene, 2020 Feb. PMID 31649333
    3. Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. Fujii S, et al. EMBO J, 2002 Oct 15. PMID 12374736, Free PMC Article
    4. The Organization of Pericentromeric Heterochromatin in Polytene Chromosome 3 of the Drosophilamelanogaster Line with the Rif1(1); SuUR(ES) Su(var)3-9(06) Mutations Suppressing Underreplication. Zykova T, et al. Cells, 2021 Oct 20. PMID 34831030, Free PMC Article
    5. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. Nagarkar-Jaiswal S, et al. Elife, 2015 Mar 31. PMID 25824290, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Apoptosis-linked gene-2
    Names
    Alg-2-PC
    CG40410-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      3623143..3627690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110989.3 → NP_001104459.2  Apoptosis-linked gene-2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104459.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y589
      Conserved Domains (2) summary
      cd00051
      Location:85 → 139
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:82 → 139
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y589 A8Y589
    Q8SYT2 Q8SYT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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