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    Nplp2 Neuropeptide-like precursor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50286, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nplp2provided by FlyBase
    Official Full Name
    Neuropeptide-like precursor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0287423
    Locus tag
    Dmel_CG11051
    See related
    AllianceGenome:FB:FBgn0287423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH08410; CG11051; DIM 7; DIM7; Dmel\CG11051; IM7; NEF; NPLP 2; nplp2; NPLP2
    Summary
    Involved in humoral immune response. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nplp2 in Genome Data Viewer
    Location:
    70A6-70A6; 3-40 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13356376..13357223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13349476..13350323)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44559 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45886 Neighboring gene uncharacterized protein Neighboring gene SoxNeuro Co-Factor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene "degrees of kevin bacon" (dokb) regulates a social network behaviour in Drosophila melanogaster. Rooke R, et al. Nat Commun, 2024 Apr 30. PMID 38688961, Free PMC Article
    2. The Exchangeable Apolipoprotein Nplp2 Sustains Lipid Flow and Heat Acclimation in Drosophila. Rommelaere S, et al. Cell Rep, 2019 Apr 16. PMID 30995484
    3. A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells. Chen J, et al. Mol Cells, 2016 Apr 30. PMID 27025390, Free PMC Article
    4. Macrophages play a nutritive role in post-metamorphic maturation in Drosophila. Krejčová G, et al. Development, 2024 Apr 1. PMID 38456486
    5. Female-specific myoinhibitory peptide neurons regulate mating receptivity in Drosophila melanogaster. Jang YH, et al. Nat Commun, 2017 Nov 21. PMID 29158481, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables neuropeptide hormone activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in humoral immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Neuropeptide-like precursor 2
    Names
    CG11051-PA
    CG11051-PB
    CG11051-PC
    NEF peptide
    Nplp2-PA
    Nplp2-PB
    Nplp2-PC
    immune induced molecule 7
    neuropeptide-like precursor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13356376..13357223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300130.1 → NP_001287059.1  Neuropeptide-like precursor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287059.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VU58
      UniProtKB/TrEMBL
      X2JB24

    2. NM_144173.3 → NP_652430.1  Neuropeptide-like precursor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VU58
      UniProtKB/TrEMBL
      X2JB24
      Related
      FBpp0075575

    3. NM_001316458.1 → NP_001303387.1  Neuropeptide-like precursor 2, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WH10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WH10 A0A0S0WH10
    Q9VU58.1 Q9VU58
    X2JB24 X2JB24

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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