COX18 membrane insertase COX18 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COX18
Official Full Name: membrane insertase COX18
Primary source: SGD:S000003294
Locus tag: YGR062C
See related: AllianceGenome:SGD:S000003294; FungiDB:YGR062C; VEuPathDB:YGR062C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OXA2
Summary: Enables membrane insertase activity. Involved in protein insertion into mitochondrial inner membrane from matrix. Located in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See COX18 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (616328..617278, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

found that YidC depletion resulted in protein aggregation/misfolding in the cytoplasm as well as in the inner membrane of E. coli
Title: Differential effect of YidC depletion on the membrane proteome of Escherichia coli under aerobic and anaerobic growth conditions.
Cox18 is able to complement the essential Sec-independent function of YidC(Escherichia coli )
Title: Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables membrane insertase activity	IBA Inferred from Biological aspect of Ancestor more info
enables membrane insertase activity	IEA Inferred from Electronic Annotation more info
enables membrane insertase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables membrane insertase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables membrane insertase activity	IPI Inferred from Physical Interaction more info	PubMed
enables membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein insertion into mitochondrial inner membrane from matrix	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: membrane insertase COX18

NP_011576.1

Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

616328..617278 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181191.1 → NP_011576.1 TPA: membrane insertase COX18 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011576.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUJ7, P53239

UniProtKB/TrEMBL

A6ZV47, C7GXP5, C8Z8V6, G2WEE9, N1P3W3

Conserved Domains (1) summary

cd20069
Location:53 → 310

5TM_Oxa1-like; Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins