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    Prosalpha3T Proteasome alpha3 subunit, Testis-specific [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosalpha3Tprovided by FlyBase
    Official Full Name
    Proteasome alpha3 subunit, Testis-specificprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261395
    Locus tag
    Dmel_CG1736
    See related
    AllianceGenome:FB:FBgn0261395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha3T; CG1736; Dmel\CG1736; Pros20S-alpha3t; prosalpha3T
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in male germ cell nucleus. Is expressed in individualization stage spermatid; mid-late elongation-stage spermatid; spermatid; and spermatozoon. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosalpha3T in Genome Data Viewer
    Location:
    100B3-100B3; 3-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31122527..31123415, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26948249..26949137, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mayo Neighboring gene uncharacterized protein Neighboring gene Ketchup

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The testis-specific proteasome subunit Prosalpha6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis. Zhong L, et al. Development, 2007 Oct. PMID 17728345
    2. Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. Palacios V, et al. J Cell Sci, 2021 Apr 1. PMID 33632744, Free PMC Article
    3. Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms. Bohm J, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11087814, Free PMC Article
    4. The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Speese SD, et al. Curr Biol, 2003 May 27. PMID 12781128
    5. On the Origin and Evolution of Drosophila New Genes during Spermatogenesis. Su Q, et al. Genes (Basel), 2021 Nov 15. PMID 34828402, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome alpha3 subunit, Testis-specific
    Names
    20s proteasome
    CG1736-PA
    Prosalpha3T-PA
    proteasome 20S alpha3t subunit
    proteasome alpha3T subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31122527..31123415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143586.3 → NP_651843.1  proteasome alpha3 subunit, Testis-specific [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DN24, Q8IS89, Q9VA12
      Related
      FBpp0085100
      Conserved Domains (2) summary
      PTZ00246
      Location:1 → 241
      PTZ00246; proteasome subunit alpha; Provisional
      cl00467
      Location:3 → 218
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA12.1 Q9VA12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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