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    Oseg5 Outer segment 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oseg5provided by FlyBase
    Official Full Name
    Outer segment 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0032891
    Locus tag
    Dmel_CG9333
    See related
    AllianceGenome:FB:FBgn0032891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9333; Che-2; CHE-2; Dmel\CG9333; IFT80; OSEG; oseg5; OSEG5
    Summary
    Involved in cilium assembly. Located in non-motile cilium. Is expressed in Johnston organ neurons; chordotonal neurons; eo neurons; and wing disc. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oseg5 in Genome Data Viewer
    Location:
    38F1-38F1; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20832849..20835840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20832849..20835840, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serpin 38F Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44307

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
    2. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301
    3. Nanotubes mediate niche-stem-cell signalling in the Drosophila testis. Inaba M, et al. Nature, 2015 Jul 16. PMID 26131929, Free PMC Article
    4. Retrotransposon-gene associations are widespread among D. melanogaster populations. Franchini LF, et al. Mol Biol Evol, 2004 Jul. PMID 15014149
    5. Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Yu J, et al. Hum Mol Genet, 2015 Mar 1. PMID 25361961

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer segment 5
    Names
    CG9333-PB
    Oseg5-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20832849..20835840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136220.3 → NP_610064.2  outer segment 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610064.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VII8
      Conserved Domains (3) summary
      COG2319
      Location:12 → 347
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:125 → 160
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:115 → 313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VII8 Q9VII8

    Gene LinkOut

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