htl heartless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: htlprovided by FlyBase
Official Full Name: heartlessprovided by FlyBase
Primary source: FLYBASE:FBgn0010389
Locus tag: Dmel_CG7223
See related: AllianceGenome:FB:FBgn0010389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7223; CT22273; CT39172; DFGF-R1; DFGF-R2; Dfr-1; DFR-1; Dfr1; DFR1; DFR1/DFGF-R2; Dmel\CG7223; DmHD-38; DPR3; dtk1; Dtk1; DTRK(FR1); EMS2; FGF-R2; FGFR; FGFR2; Fr1; FR1; HD-38; Htl; HTL/FGFR1; i100; i150; i79; j372; Tk1
Summary: Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including formation of primary germ layer; gliogenesis; and larval development. Acts upstream of with a positive effect on glial cell projection elongation. Located in postsynapse of neuromuscular junction. Is active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; glial cell; larval sheath cell of ovary; muscle cell; and trunk visceral muscle primordium. Used to study high grade glioma. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to several human genes including FGFR1 (fibroblast growth factor receptor 1); FGFR2 (fibroblast growth factor receptor 2); and FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 90E2-90E2; 3-62 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18045216..18052984, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13870938..13878706, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signalling.
Title: SILAC-based quantitative proteomic analysis of Drosophila gastrula stage embryos mutant for fibroblast growth factor signalling.
Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.
Title: Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.
FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
Title: FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
Mactosylceramide, an early product in GSL biosynthesis, prevents inappropriate activation of insulin and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Title: Mactosylceramide prevents glial cell overgrowth by inhibiting insulin and fibroblast growth factor receptor signaling.
Proliferation of epithelial sheath progenitors, the apical cells, was decreased in both htl and ths mutants, while ectopic expression of the Ths ligand led to these cells' over-proliferation suggesting that FGF signaling supports ovarian muscle sheath formation by controlling apical cell number in the developing gonad.
Title: FGF signaling supports Drosophila fertility by regulating development of ovarian muscle tissues.
Our data identify FGF signaling through Heartless as a key regulator of astrocyte morphological elaboration in vivo.
Title: Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
Title: Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function.
Mesodermal cell spreading is dependent on the FGF receptor Heartless.
Title: Photoactivatable GFP resolves Drosophila mesoderm migration behaviour.
Htl is essential for the differentiation of dorsal mesodermal derivatives
Title: FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula.
Activation of Htl signalling produces a less prominent effect on FGF pathway on dorsal muscles than on lateral muscles.Extra founders of dorsal muscles are located in characteristic fashion that is different from that observed for excess lateral founders.
Title: Drosophila Heartless acts with Heartbroken/Dof in muscle founder differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in endodermal cell fate determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect glial cell projection elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland crystal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland plasmatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myotube cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visceral muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse of neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heartless

Names: CG7223-PA; CG7223-PB; CG7223-PC; FGF receptor; fibroblast growth factor receptor; fibroblast growth factor receptor 1; htl-PA; htl-PB; htl-PC

NP_524394.2

EC 2.7.10.1

NP_732286.1

EC 2.7.10.1

NP_732287.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18045216..18052984 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079670.3 → NP_524394.2 heartless, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524394.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V320, O18371, Q07407, Q26294, Q9VED5

Related

FBpp0082970

Conserved Domains (4) summary

smart00221
Location:416 → 688

STYKc; Protein kinase; unclassified specificity

smart00410
Location:113 → 191

IG_like; Immunoglobulin like

cl11960
Location:112 → 191

Ig; Immunoglobulin domain

cl21453
Location:404 → 692

PKc_like; Protein Kinases, catalytic domain
NM_169785.2 → NP_732287.1 heartless, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732287.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V320, O18371, Q07407, Q26294, Q9VED5

Related

FBpp0082972

Conserved Domains (4) summary

smart00221
Location:416 → 688

STYKc; Protein kinase; unclassified specificity

smart00410
Location:113 → 191

IG_like; Immunoglobulin like

cl11960
Location:112 → 191

Ig; Immunoglobulin domain

cl21453
Location:404 → 692

PKc_like; Protein Kinases, catalytic domain
NM_169784.2 → NP_732286.1 heartless, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732286.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V320, O18371, Q07407, Q26294, Q9VED5

Related

FBpp0082971

Conserved Domains (4) summary

smart00221
Location:416 → 688

STYKc; Protein kinase; unclassified specificity

smart00410
Location:113 → 191

IG_like; Immunoglobulin like

cl11960
Location:112 → 191

Ig; Immunoglobulin domain

cl21453
Location:404 → 692

PKc_like; Protein Kinases, catalytic domain