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    Lyz2 lysozyme 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lyz2provided by RGD
    Official Full Name
    lysozyme 2provided by RGD
    Primary source
    RGD:3026
    See related
    EnsemblRapid:ENSRNOG00000005825 AllianceGenome:RGD:3026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lyz; Lysz; Lyz1
    Summary
    Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 51113.8) and Spleen (RPKM 4301.1) See more
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    Genomic context

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    See Lyz2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54792715..54798060, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52906810..52912154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60335968..60341264, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene similar to RIKEN cDNA 9530003J23 Neighboring gene lysozyme C type 2 Neighboring gene cleavage and polyadenylation specific factor 6 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120093601

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Primary structure of rat lysozyme. White TJ, et al. Biochemistry, 1977 Apr 5. PMID 851497
    2. Bactericidal activity of testicular macrophages. Wei RQ, et al. Biol Reprod, 1988 May. PMID 2840982
    3. Lysozyme expression in the rat parotid gland: light and electron microscopic immunogold studies. Staneva-Dobrovski L. Histochem Cell Biol, 1997 May. PMID 9208328
    4. Role of acid back-diffusion, glutathione, oxyradical, and histamine in antral hemorrhagic ulcer in rats: the protective effect of lysozyme chloride and antioxidants. Hung CR, et al. J Lab Clin Med, 2002 Sep. PMID 12271271
    5. Effects of lead administration at low doses by different routes on rat spleens. Study of response of splenic lymphocytes and tissue lysozyme. Teijón C, et al. Toxicology, 2003 Sep 30. PMID 12965127

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lysozyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysozyme C-1
    Names
    1,4-beta-N-acetylmuramidase C
    NP_036903.2
    XP_038934368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012771.3 → NP_036903.2  lysozyme C-1 precursor

      See identical proteins and their annotated locations for NP_036903.2

      Status: PROVISIONAL

      Source sequence(s)
      BC058490
      UniProtKB/Swiss-Prot
      P00697
      UniProtKB/TrEMBL
      A0A077S1I6, Q6PDV1
      Related
      ENSRNOP00000088305.2, ENSRNOT00000097754.2
      Conserved Domains (1) summary
      smart00263
      Location:19 → 147
      LYZ1; Alpha-lactalbumin / lysozyme C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54792715..54798060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078440.2 → XP_038934368.1  lysozyme C-1 isoform X1

      UniProtKB/TrEMBL
      F1M8E9
      Related
      ENSRNOP00000007747.5, ENSRNOT00000007747.9
      Conserved Domains (1) summary
      smart00263
      Location:19 → 191
      LYZ1; Alpha-lactalbumin / lysozyme C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00697.2 GenPept UniProtKB/Swiss-Prot:P00697

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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