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    Fkbp8 FKBP prolyl isomerase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbp8provided by RGD
    Official Full Name
    FKBP prolyl isomerase 8provided by RGD
    Primary source
    RGD:1308670
    See related
    EnsemblRapid:ENSRNOG00000058359 AllianceGenome:RGD:1308670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FKBP-8
    Summary
    Predicted to enable several functions, including calmodulin binding activity; disordered domain specific binding activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of protein phosphorylation; protein folding; and regulation of mitophagy. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytosol; endomembrane system; and mitochondrial envelope. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 633.4), Adrenal (RPKM 583.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbp8 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18929581..18936621, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18895608..18902648, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20645956..20652890, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inositol-3-phosphate synthase 1 Neighboring gene elongation factor for RNA polymerase II Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication. Li H, et al. Virus Genes, 2016 Feb. PMID 26748656
    2. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. Okamoto T, et al. EMBO J, 2006 Oct 18. PMID 17024179, Free PMC Article
    3. The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). Kang CB, et al. FEBS Lett, 2005 Feb 28. PMID 15733859
    4. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, et al. Hum Mol Genet, 2008 Feb 15. PMID 18003640
    5. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Mali GR, et al. Elife, 2018 Jun 19. PMID 29916806, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125185

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP8
    Names
    FK506 binding protein 8, 38kDa
    FK506-binding protein 8
    PPIase FKBP8
    rotamase
    NP_001032257.1
    XP_038950249.1
    XP_038950250.1
    XP_038950251.1
    XP_038950254.1
    XP_038950255.1
    XP_038950256.1
    XP_063131232.1
    XP_063131233.1
    XP_063131234.1
    XP_063131235.1
    XP_063131236.1
    XP_063131237.1
    XP_063131239.1
    XP_063131240.1
    XP_063131241.1
    XP_063131242.1
    XP_063131243.1
    XP_063131244.1
    XP_063131245.1
    XP_063131246.1
    XP_063131247.1
    XP_063131248.1
    XP_063131249.1
    XP_063131250.1
    XP_063131251.1
    XP_063131252.1
    XP_063131253.1
    XP_063131254.1
    XP_063131255.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037180.1 → NP_001032257.1  peptidyl-prolyl cis-trans isomerase FKBP8

      See identical proteins and their annotated locations for NP_001032257.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107454
      UniProtKB/Swiss-Prot
      Q3B7U9
      UniProtKB/TrEMBL
      A0A8I6A3K9
      Related
      ENSRNOP00000087668.1, ENSRNOT00000095622.2
      Conserved Domains (3) summary
      COG0457
      Location:206 → 329
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 292
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 192
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18929581..18936621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094327.1 → XP_038950255.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3K9
      Conserved Domains (3) summary
      COG0457
      Location:205 → 328
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:244 → 291
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 191
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. XM_063275173.1 → XP_063131243.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

    3. XM_063275163.1 → XP_063131233.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

    4. XM_039094321.2 → XP_038950249.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3K9
      Related
      ENSRNOP00000074539.2, ENSRNOT00000077756.3
      Conserved Domains (3) summary
      COG0457
      Location:206 → 336
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 192
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    5. XM_063275174.1 → XP_063131244.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

    6. XM_039094328.2 → XP_038950256.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3K9
      Conserved Domains (3) summary
      COG0457
      Location:205 → 328
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:244 → 291
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 191
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    7. XM_063275180.1 → XP_063131250.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

      UniProtKB/Swiss-Prot
      Q3B7U9
      UniProtKB/TrEMBL
      A0A8I6A3K9

    8. XM_063275181.1 → XP_063131251.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

      UniProtKB/Swiss-Prot
      Q3B7U9
      UniProtKB/TrEMBL
      A0A8I6A3K9

    9. XM_063275172.1 → XP_063131242.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

    10. XM_063275184.1 → XP_063131254.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3K9

    11. XM_063275166.1 → XP_063131236.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

    12. XM_063275162.1 → XP_063131232.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

    13. XM_063275176.1 → XP_063131246.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

    14. XM_063275169.1 → XP_063131239.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

    15. XM_063275178.1 → XP_063131248.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A3K9

    16. XM_039094323.2 → XP_038950251.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3K9
      Conserved Domains (3) summary
      COG0457
      Location:206 → 336
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 192
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    17. XM_063275177.1 → XP_063131247.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3K9

    18. XM_039094326.1 → XP_038950254.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

      UniProtKB/Swiss-Prot
      Q3B7U9
      UniProtKB/TrEMBL
      A0A8I6A3K9
      Conserved Domains (3) summary
      COG0457
      Location:206 → 329
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:245 → 292
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 192
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    19. XM_063275164.1 → XP_063131234.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

    20. XM_063275183.1 → XP_063131253.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3K9

    21. XM_063275175.1 → XP_063131245.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

    22. XM_063275170.1 → XP_063131240.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

    23. XM_039094322.2 → XP_038950250.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A3K9
      Conserved Domains (3) summary
      COG0457
      Location:206 → 336
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:270 → 298
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:103 → 192
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    24. XM_063275179.1 → XP_063131249.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A3K9

    25. XM_063275167.1 → XP_063131237.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

    26. XM_063275182.1 → XP_063131252.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

      UniProtKB/Swiss-Prot
      Q3B7U9
      UniProtKB/TrEMBL
      A0A8I6A3K9

    27. XM_063275185.1 → XP_063131255.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A3K9

    28. XM_063275165.1 → XP_063131235.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

    29. XM_063275171.1 → XP_063131241.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7U9.1 GenPept UniProtKB/Swiss-Prot:Q3B7U9

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