Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Baiap2l1provided by RGD
Official Full Name: BAR/IMD domain containing adaptor protein 2 like 1provided by RGD
Primary source: RGD:1308452
See related: EnsemblRapid:ENSRNOG00000001007 AllianceGenome:RGD:1308452
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308452
Summary: Predicted to enable proline-rich region binding activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be active in cytosol and nucleoplasm. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 76.5), Liver (RPKM 67.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15364090..15453602)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10250434..10339937)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12226967..12321172)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU046504 (e-PCR)
- UniSTS:111387

RH128970 (e-PCR)
- UniSTS:212278

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Names: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034140.1 → NP_001029312.1 BAR/IMD domain-containing adapter protein 2-like 1

See identical proteins and their annotated locations for NP_001029312.1

Status: PROVISIONAL

Source sequence(s)

BC105815

UniProtKB/Swiss-Prot

Q3KR97, Q5FWT2

UniProtKB/TrEMBL

A0A8L2QTC2

Related

ENSRNOP00000075796.3, ENSRNOT00000092610.3

Conserved Domains (2) summary

cd07645
Location:6 → 231

I-BAR_IMD_BAIAP2L1; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1

cd11913
Location:343 → 400

SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

15364090..15453602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598315.3 → XP_017453804.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A8L2QTC2

Related

ENSRNOP00000057568.6, ENSRNOT00000060843.6
XM_063271253.1 → XP_063127323.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8L2RB03
XM_063271254.1 → XP_063127324.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3
XM_039089346.2 → XP_038945274.1 brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3

Conserved Domains (4) summary

cd11913
Location:234 → 291

SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)

cd21762
Location:393 → 396

WH2; actin-binding sequence [structural motif]

cl12013
Location:1 → 117

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl41728
Location:391 → 406

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins