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    Dcaf17 DDB1 and CUL4 associated factor 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf17provided by RGD
    Official Full Name
    DDB1 and CUL4 associated factor 17provided by RGD
    Primary source
    RGD:1565551
    See related
    EnsemblRapid:ENSRNOG00000009403 AllianceGenome:RGD:1565551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565551
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in Woodhouse-Sakati syndrome. Orthologous to human DCAF17 (DDB1 and CUL4 associated factor 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 82.6), Lung (RPKM 77.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf17 in Genome Data Viewer
    Location:
    3q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76271503..76303321)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55863776..55895601)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57646799..57678802)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 8, tRNA N3-cytidine Neighboring gene uncharacterized LOC134486104 Neighboring gene uncharacterized LOC134486103 Neighboring gene cytochrome b reductase 1 Neighboring gene uncharacterized LOC134486105 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177688.2 → NP_001171159.1  DDB1- and CUL4-associated factor 17 isoform 1

      See identical proteins and their annotated locations for NP_001171159.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      B1H299
      UniProtKB/TrEMBL
      A0A140TAE5
      Conserved Domains (1) summary
      pfam15802
      Location:31 → 473
      DCAF17; DDB1- and CUL4-associated factor 17

    2. NM_001398928.1 → NP_001385857.1  DDB1- and CUL4-associated factor 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A140TAE5, A6HM38
      Related
      ENSRNOP00000097480.2, ENSRNOT00000098494.2
      Conserved Domains (1) summary
      pfam15802
      Location:31 → 504
      DCAF17; DDB1- and CUL4-associated factor 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      76271503..76303321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284357.1 → XP_063140427.1  DDB1- and CUL4-associated factor 17 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV09
      Related
      ENSRNOP00000031374.7, ENSRNOT00000031463.7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1H299.1 GenPept UniProtKB/Swiss-Prot:B1H299

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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